I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| enteroendocrine cell | 3 studies | 32% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| enteroendocrine cell | 3 studies | 32% ± 10% |
Insufficient scRNA-seq data for expression of GHRL at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 100% | 102.31 | 327 / 328 | 70% | 4.89 | 124 / 178 |
| brain | 87% | 25.05 | 2287 / 2642 | 64% | 1.26 | 454 / 705 |
| prostate | 99% | 62.28 | 243 / 245 | 48% | 0.77 | 240 / 502 |
| thymus | 100% | 94.09 | 652 / 653 | 44% | 0.81 | 268 / 605 |
| stomach | 99% | 8818.96 | 356 / 359 | 36% | 2.81 | 103 / 286 |
| breast | 96% | 41.61 | 439 / 459 | 39% | 0.91 | 441 / 1118 |
| kidney | 98% | 44.61 | 87 / 89 | 34% | 0.61 | 309 / 901 |
| ovary | 97% | 37.05 | 174 / 180 | 35% | 0.71 | 151 / 430 |
| lung | 95% | 49.20 | 549 / 578 | 33% | 0.72 | 380 / 1155 |
| esophagus | 86% | 34.24 | 1236 / 1445 | 33% | 2.52 | 61 / 183 |
| uterus | 99% | 36.69 | 168 / 170 | 19% | 0.61 | 86 / 459 |
| intestine | 94% | 66.94 | 910 / 966 | 21% | 2.31 | 112 / 527 |
| bladder | 90% | 24.71 | 19 / 21 | 17% | 0.38 | 87 / 504 |
| adrenal gland | 93% | 26.97 | 240 / 258 | 12% | 0.22 | 28 / 230 |
| spleen | 100% | 130.04 | 241 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 122.61 | 907 / 929 | 0% | 0 | 0 / 0 |
| skin | 79% | 22.50 | 1437 / 1809 | 17% | 0.36 | 78 / 472 |
| adipose | 94% | 31.54 | 1133 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 5.41 | 27 / 29 |
| liver | 84% | 22.06 | 189 / 226 | 9% | 0.15 | 35 / 406 |
| blood vessel | 88% | 25.55 | 1171 / 1335 | 0% | 0 | 0 / 0 |
| heart | 68% | 14.99 | 584 / 861 | 0% | 0 | 0 / 0 |
| muscle | 61% | 11.59 | 489 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 42% | 0.78 | 19 / 45 |
| eye | 0% | 0 | 0 / 0 | 4% | 0.08 | 3 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0060124 | Biological process | positive regulation of growth hormone secretion |
| GO_0060399 | Biological process | positive regulation of growth hormone receptor signaling pathway |
| GO_1903012 | Biological process | positive regulation of bone development |
| GO_1904179 | Biological process | positive regulation of adipose tissue development |
| GO_0043627 | Biological process | response to estrogen |
| GO_1905333 | Biological process | regulation of gastric motility |
| GO_0032715 | Biological process | negative regulation of interleukin-6 production |
| GO_0040010 | Biological process | positive regulation of growth rate |
| GO_0051602 | Biological process | response to electrical stimulus |
| GO_0040013 | Biological process | negative regulation of locomotion |
| GO_0030252 | Biological process | growth hormone secretion |
| GO_0060079 | Biological process | excitatory postsynaptic potential |
| GO_0046697 | Biological process | decidualization |
| GO_1904349 | Biological process | positive regulation of small intestine smooth muscle contraction |
| GO_0008343 | Biological process | adult feeding behavior |
| GO_0120058 | Biological process | positive regulation of small intestinal transit |
| GO_1904346 | Biological process | positive regulation of gastric mucosal blood circulation |
| GO_1905564 | Biological process | positive regulation of vascular endothelial cell proliferation |
| GO_1903672 | Biological process | positive regulation of sprouting angiogenesis |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_1904000 | Biological process | positive regulation of eating behavior |
| GO_0046676 | Biological process | negative regulation of insulin secretion |
| GO_0032691 | Biological process | negative regulation of interleukin-1 beta production |
| GO_0008154 | Biological process | actin polymerization or depolymerization |
| GO_0032024 | Biological process | positive regulation of insulin secretion |
| GO_0051464 | Biological process | positive regulation of cortisol secretion |
| GO_0016525 | Biological process | negative regulation of angiogenesis |
| GO_0035774 | Biological process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| GO_0009725 | Biological process | response to hormone |
| GO_0001937 | Biological process | negative regulation of endothelial cell proliferation |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0050728 | Biological process | negative regulation of inflammatory response |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0040018 | Biological process | positive regulation of multicellular organism growth |
| GO_0032100 | Biological process | positive regulation of appetite |
| GO_0046010 | Biological process | positive regulation of circadian sleep/wake cycle, non-REM sleep |
| GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
| GO_0009755 | Biological process | hormone-mediated signaling pathway |
| GO_0043400 | Biological process | cortisol secretion |
| GO_0099170 | Biological process | postsynaptic modulation of chemical synaptic transmission |
| GO_0051461 | Biological process | positive regulation of corticotropin secretion |
| GO_0007416 | Biological process | synapse assembly |
| GO_0051969 | Biological process | regulation of transmission of nerve impulse |
| GO_0001696 | Biological process | gastric acid secretion |
| GO_0032720 | Biological process | negative regulation of tumor necrosis factor production |
| GO_0032095 | Biological process | regulation of response to food |
| GO_0016358 | Biological process | dendrite development |
| GO_0051965 | Biological process | positive regulation of synapse assembly |
| GO_0051216 | Biological process | cartilage development |
| GO_0006006 | Biological process | glucose metabolic process |
| GO_0042127 | Biological process | regulation of cell population proliferation |
| GO_0099175 | Biological process | regulation of postsynapse organization |
| GO_0042322 | Biological process | negative regulation of circadian sleep/wake cycle, REM sleep |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
| GO_0098794 | Cellular component | postsynapse |
| GO_0034774 | Cellular component | secretory granule lumen |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0030424 | Cellular component | axon |
| GO_0001664 | Molecular function | G protein-coupled receptor binding |
| GO_0030296 | Molecular function | protein tyrosine kinase activator activity |
| GO_0031768 | Molecular function | ghrelin receptor binding |
| GO_0016608 | Molecular function | growth hormone-releasing hormone activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | GHRL |
| Protein name | Ghrelin Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) (Protein M46) [Cleaved into: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin] Ghrelin and obestatin prepropeptide Ghrelin and obestatin prepropeptide (Ghrelin splice variant) |
| Synonyms | MTLRP UNQ524/PRO1066 |
| Description | FUNCTION: [Ghrelin-27]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) . Induces the release of growth hormone from the pituitary . Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. .; FUNCTION: [Ghrelin-28]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) . Induces the release of growth hormone from the pituitary . Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. .; FUNCTION: [Obestatin]: May be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity). . FUNCTION: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. .; FUNCTION: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility. . |
| Accessions | Q9UBU3 ENST00000446937.2 I6N821 ENST00000449238.6 [Q9UBU3-4] ENST00000287656.11 [Q9UBU3-2] A0A0R5QLN9 ENST00000439975.6 [Q9UBU3-5] A2T3X2 ENST00000425479.1 ENST00000430179.5 [Q9UBU3-2] ENST00000335542.13 [Q9UBU3-1] ENST00000422159.5 [Q9UBU3-6] E7ESW0 ENST00000429122.1 [Q9UBU3-1] A2T3X4 A8DN24 ENST00000457360.5 [Q9UBU3-1] A2T3X3 A2T3X5 ENST00000437422.6 [Q9UBU3-3] |
