DEFB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019722Biological processcalcium-mediated signaling
GO_0045087Biological processinnate immune response
GO_0019731Biological processantibacterial humoral response
GO_0009617Biological processresponse to bacterium
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0060474Biological processpositive regulation of flagellated sperm motility involved in capacitation
GO_0006935Biological processchemotaxis
GO_0006955Biological processimmune response
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0042742Biological processdefense response to bacterium
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0002227Biological processinnate immune response in mucosa
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_1990742Cellular componentmicrovesicle
GO_0005796Cellular componentGolgi lumen
GO_0070062Cellular componentextracellular exosome
GO_0097225Cellular componentsperm midpiece
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0031731Molecular functionCCR6 chemokine receptor binding

IV. Literature review

[source]
Gene nameDEFB1
Protein nameBeta-defensin 1 (BD-1) (hBD-1) (Defensin, beta 1)
SynonymsBD1
HBD1
DescriptionFUNCTION: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility . .

AccessionsENST00000642865.2
P60022
ENST00000297439.4