RIC8A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071711Biological processbasement membrane organization
GO_0001944Biological processvasculature development
GO_0070586Biological processcell-cell adhesion involved in gastrulation
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0001701Biological processin utero embryonic development
GO_0042074Biological processcell migration involved in gastrulation
GO_0008542Biological processvisual learning
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0001965Molecular functionG-protein alpha-subunit binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRIC8A
Protein nameRIC8 guanine nucleotide exchange factor A
Synembryn (Protein Ric-8)
Synembryn-A (Protein Ric-8A)
Synonyms
DescriptionFUNCTION: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. .

FUNCTION: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. .

FUNCTION: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. .

FUNCTION: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. .

FUNCTION: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. .

FUNCTION: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. .

AccessionsH0YEN0
E9PSI0
ENST00000530889.1
E9PI04
ENST00000524854.5
E9PLE5
ENST00000529275.1
H0YC88
Q9NPQ8
ENST00000527728.1
ENST00000528357.5
ENST00000325207.9 [Q9NPQ8-3]
E9PMP0
H0YE35
ENST00000626818.1
ENST00000527696.5 [Q9NPQ8-2]
ENST00000526104.6 [Q9NPQ8-1]
ENST00000526982.1
ENST00000527468.1