Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 10 studies | 29% ± 10% | |
| fibroblast | 7 studies | 22% ± 7% | |
| myofibroblast cell | 4 studies | 22% ± 9% | |
| endothelial cell | 4 studies | 23% ± 4% | |
| smooth muscle cell | 3 studies | 26% ± 13% | |
| connective tissue cell | 3 studies | 33% ± 18% |
Insufficient scRNA-seq data for expression of S1PR3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 98% | 4491.25 | 240 / 245 | 88% | 6.49 | 442 / 502 |
| breast | 85% | 1554.67 | 391 / 459 | 97% | 14.87 | 1083 / 1118 |
| adrenal gland | 99% | 4732.38 | 256 / 258 | 79% | 13.16 | 182 / 230 |
| lung | 89% | 1832.53 | 515 / 578 | 83% | 5.49 | 959 / 1155 |
| bladder | 100% | 4211.24 | 21 / 21 | 71% | 5.41 | 356 / 504 |
| kidney | 93% | 3980.60 | 83 / 89 | 70% | 9.87 | 635 / 901 |
| esophagus | 80% | 9651.60 | 1157 / 1445 | 76% | 7.66 | 139 / 183 |
| uterus | 96% | 3834.54 | 163 / 170 | 59% | 7.13 | 270 / 459 |
| intestine | 79% | 2297.31 | 767 / 966 | 61% | 3.53 | 320 / 527 |
| thymus | 61% | 885.50 | 401 / 653 | 74% | 3.16 | 447 / 605 |
| stomach | 60% | 2068.38 | 217 / 359 | 72% | 5.77 | 207 / 286 |
| brain | 31% | 436.34 | 813 / 2642 | 94% | 14.72 | 662 / 705 |
| pancreas | 17% | 171.10 | 56 / 328 | 91% | 6.76 | 162 / 178 |
| ovary | 27% | 856.80 | 49 / 180 | 77% | 5.92 | 332 / 430 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.98 | 1 / 1 |
| blood vessel | 100% | 9582.43 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 94% | 2214.06 | 227 / 241 | 0% | 0 | 0 / 0 |
| adipose | 93% | 2455.52 | 1121 / 1204 | 0% | 0 | 0 / 0 |
| heart | 90% | 2297.10 | 773 / 861 | 0% | 0 | 0 / 0 |
| skin | 43% | 1766.33 | 776 / 1809 | 44% | 3.26 | 207 / 472 |
| liver | 27% | 360.28 | 60 / 226 | 46% | 2.44 | 187 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 62% | 4.69 | 18 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 60% | 2.99 | 27 / 45 |
| muscle | 15% | 179.56 | 124 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 8% | 0.26 | 6 / 80 |
| peripheral blood | 5% | 49.83 | 42 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006954 | Biological process | inflammatory response |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_1903141 | Biological process | negative regulation of establishment of endothelial barrier |
| GO_0003376 | Biological process | sphingosine-1-phosphate receptor signaling pathway |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0007193 | Biological process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| GO_0032651 | Biological process | regulation of interleukin-1 beta production |
| GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO_0009653 | Biological process | anatomical structure morphogenesis |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0019222 | Biological process | regulation of metabolic process |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0004930 | Molecular function | G protein-coupled receptor activity |
| GO_0008289 | Molecular function | lipid binding |
| GO_0005178 | Molecular function | integrin binding |
| GO_0038036 | Molecular function | sphingosine-1-phosphate receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | S1PR3 |
| Protein name | Sphingosine 1-phosphate receptor 3 (S1P receptor 3) (S1P3) (Endothelial differentiation G-protein coupled receptor 3) (Sphingosine 1-phosphate receptor Edg-3) (S1P receptor Edg-3) |
| Synonyms | EDG3 C9orf108 C9orf47 |
| Description | FUNCTION: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. . |
| Accessions | Q99500 ENST00000375846.3 ENST00000358157.3 |
