GNG5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	39 studies	39% ± 15%	Explore
macrophage	38 studies	62% ± 20%	Explore
endothelial cell	38 studies	54% ± 20%	Explore
natural killer cell	36 studies	45% ± 15%	Explore
fibroblast	36 studies	45% ± 16%	Explore
CD8-positive, alpha-beta T cell	35 studies	41% ± 21%	Explore
T cell	29 studies	41% ± 17%	Explore
CD4-positive, alpha-beta T cell	29 studies	41% ± 20%	Explore
conventional dendritic cell	28 studies	74% ± 16%	Explore
classical monocyte	26 studies	70% ± 16%	Explore
regulatory T cell	26 studies	44% ± 18%	Explore
pericyte	26 studies	43% ± 16%	Explore
smooth muscle cell	25 studies	44% ± 20%	Explore
dendritic cell	24 studies	67% ± 25%	Explore
non-classical monocyte	24 studies	80% ± 15%	Explore
plasmacytoid dendritic cell	23 studies	68% ± 16%	Explore
monocyte	21 studies	61% ± 21%	Explore
plasma cell	21 studies	48% ± 21%	Explore
epithelial cell	21 studies	68% ± 16%	Explore
basal cell	20 studies	54% ± 20%	Explore
mast cell	19 studies	41% ± 17%	Explore
memory B cell	19 studies	38% ± 11%	Explore
mature NK T cell	18 studies	40% ± 10%	Explore
endothelial cell of lymphatic vessel	17 studies	62% ± 14%	Explore
naive B cell	17 studies	35% ± 9%	Explore
connective tissue cell	17 studies	51% ± 20%	Explore
gamma-delta T cell	17 studies	42% ± 14%	Explore
ciliated cell	16 studies	65% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	46% ± 14%	Explore
myeloid cell	15 studies	61% ± 25%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	31% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	40% ± 13%	Explore
neutrophil	13 studies	43% ± 17%	Explore
capillary endothelial cell	13 studies	50% ± 18%	Explore
myofibroblast cell	13 studies	50% ± 17%	Explore
secretory cell	12 studies	66% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	38% ± 11%	Explore
endothelial cell of artery	12 studies	58% ± 17%	Explore
mucosal invariant T cell	12 studies	33% ± 9%	Explore
plasmablast	11 studies	64% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	43% ± 18%	Explore
goblet cell	11 studies	44% ± 20%	Explore
vein endothelial cell	11 studies	65% ± 17%	Explore
endothelial cell of vascular tree	11 studies	59% ± 14%	Explore
type II pneumocyte	10 studies	59% ± 29%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	44% ± 19%	Explore
progenitor cell	10 studies	62% ± 18%	Explore
abnormal cell	10 studies	46% ± 20%	Explore
mesothelial cell	10 studies	65% ± 22%	Explore
type I pneumocyte	9 studies	57% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	40% ± 9%	Explore
innate lymphoid cell	8 studies	37% ± 11%	Explore
club cell	8 studies	62% ± 18%	Explore
platelet	8 studies	26% ± 11%	Explore
leukocyte	8 studies	51% ± 14%	Explore
enterocyte	8 studies	49% ± 18%	Explore
T follicular helper cell	8 studies	43% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	55% ± 21%	Explore
epithelial cell of proximal tubule	7 studies	48% ± 13%	Explore
IgG plasma cell	7 studies	30% ± 16%	Explore
erythrocyte	7 studies	49% ± 25%	Explore
alveolar macrophage	6 studies	73% ± 21%	Explore
hematopoietic precursor cell	6 studies	50% ± 22%	Explore
respiratory goblet cell	6 studies	53% ± 16%	Explore
mononuclear phagocyte	6 studies	58% ± 20%	Explore
kidney loop of Henle epithelial cell	6 studies	51% ± 10%	Explore
renal alpha-intercalated cell	6 studies	61% ± 10%	Explore
erythroblast	6 studies	46% ± 27%	Explore
IgA plasma cell	6 studies	32% ± 17%	Explore
microglial cell	6 studies	40% ± 19%	Explore
hematopoietic stem cell	6 studies	57% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	47% ± 20%	Explore
CD4-positive helper T cell	5 studies	27% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	37% ± 11%	Explore
exhausted T cell	5 studies	59% ± 10%	Explore
ionocyte	5 studies	50% ± 17%	Explore
transit amplifying cell	5 studies	47% ± 24%	Explore
precursor B cell	5 studies	60% ± 12%	Explore
pro-B cell	5 studies	49% ± 23%	Explore
brush cell	5 studies	34% ± 25%	Explore
double negative thymocyte	5 studies	57% ± 21%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	61% ± 21%	Explore
intermediate monocyte	5 studies	85% ± 8%	Explore
granulocyte	5 studies	43% ± 18%	Explore
deuterosomal cell	4 studies	57% ± 20%	Explore
pancreatic A cell	4 studies	62% ± 23%	Explore
glomerular endothelial cell	4 studies	46% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	67% ± 6%	Explore
enteroendocrine cell	4 studies	65% ± 11%	Explore
intestinal crypt stem cell	4 studies	49% ± 18%	Explore
immature B cell	4 studies	56% ± 10%	Explore
neuron	4 studies	37% ± 7%	Explore
astrocyte	4 studies	26% ± 14%	Explore
adventitial cell	4 studies	34% ± 1%	Explore
mucus secreting cell	4 studies	47% ± 9%	Explore
acinar cell	4 studies	53% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	72% ± 4%	Explore
hepatocyte	4 studies	52% ± 27%	Explore
T-helper 17 cell	4 studies	46% ± 26%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	54% ± 26%	Explore
duct epithelial cell	3 studies	57% ± 18%	Explore
precursor cell	3 studies	83% ± 9%	Explore
squamous epithelial cell	3 studies	62% ± 26%	Explore
pancreatic D cell	3 studies	56% ± 29%	Explore
type B pancreatic cell	3 studies	52% ± 14%	Explore
monocyte-derived dendritic cell	3 studies	73% ± 22%	Explore
podocyte	3 studies	62% ± 7%	Explore
neural crest cell	3 studies	74% ± 11%	Explore
renal principal cell	3 studies	63% ± 15%	Explore
extravillous trophoblast	3 studies	87% ± 6%	Explore
placental villous trophoblast	3 studies	85% ± 2%	Explore
lymphocyte	3 studies	68% ± 12%	Explore
megakaryocyte	3 studies	52% ± 6%	Explore
neuroendocrine cell	3 studies	58% ± 23%	Explore
serous secreting cell	3 studies	54% ± 3%	Explore
tissue-resident macrophage	3 studies	43% ± 19%	Explore
intraepithelial lymphocyte	3 studies	45% ± 19%	Explore
Mueller cell	3 studies	58% ± 9%	Explore
muscle cell	3 studies	47% ± 16%	Explore
germinal center B cell	3 studies	64% ± 9%	Explore
myoepithelial cell	3 studies	56% ± 15%	Explore
inflammatory macrophage	3 studies	38% ± 8%	Explore
luminal cell of prostate epithelium	3 studies	65% ± 7%	Explore
IgM plasma cell	3 studies	39% ± 16%	Explore
pancreatic ductal cell	3 studies	85% ± 4%	Explore
glial cell	3 studies	53% ± 23%	Explore
group 3 innate lymphoid cell	3 studies	50% ± 18%	Explore
keratinocyte	3 studies	40% ± 2%	Explore
T-helper 1 cell	3 studies	53% ± 24%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	35% ± 10%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	36% ± 11%	Explore
progenitor cell of mammary luminal epithelium	3 studies	54% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	49% ± 12%	Explore
lung	18 studies	55% ± 18%	Explore
intestine	13 studies	42% ± 21%	Explore
kidney	9 studies	48% ± 12%	Explore
liver	6 studies	45% ± 23%	Explore
pancreas	5 studies	55% ± 20%	Explore
bone marrow	5 studies	40% ± 21%	Explore
uterus	5 studies	54% ± 20%	Explore
lymph node	5 studies	50% ± 20%	Explore
placenta	4 studies	69% ± 20%	Explore
eye	4 studies	30% ± 7%	Explore
brain	4 studies	37% ± 12%	Explore
prostate	4 studies	49% ± 9%	Explore
breast	4 studies	54% ± 1%	Explore
adrenal gland	3 studies	38% ± 4%	Explore
esophagus	3 studies	52% ± 24%	Explore
skin	3 studies	33% ± 7%	Explore
thymus	3 studies	58% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3429.31	1445 / 1445	100%	23.57	183 / 183
ovary	100%	2232.66	180 / 180	100%	40.52	429 / 430
uterus	100%	2961.14	170 / 170	99%	19.85	454 / 459
stomach	100%	3242.24	359 / 359	99%	36.10	282 / 286
lung	100%	4972.48	578 / 578	98%	14.56	1133 / 1155
intestine	100%	3649.42	966 / 966	98%	34.25	516 / 527
bladder	100%	3070.24	21 / 21	98%	26.94	492 / 504
skin	100%	3265.54	1808 / 1809	98%	16.99	461 / 472
thymus	100%	3484.02	653 / 653	97%	14.19	586 / 605
prostate	100%	3062.64	245 / 245	95%	13.77	477 / 502
pancreas	100%	2004.16	327 / 328	95%	20.49	169 / 178
kidney	100%	4337.08	89 / 89	92%	10.38	830 / 901
liver	100%	2714.40	226 / 226	92%	13.55	372 / 406
breast	100%	3483.48	459 / 459	91%	11.63	1020 / 1118
adrenal gland	100%	2671.15	258 / 258	86%	8.49	197 / 230
brain	81%	1156.80	2139 / 2642	76%	13.11	533 / 705
adipose	100%	3695.07	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	17.76	80 / 80
lymph node	0%	0	0 / 0	100%	21.14	29 / 29
muscle	100%	4475.06	803 / 803	0%	0	0 / 0
spleen	100%	4466.39	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	15.77	45 / 45
ureter	0%	0	0 / 0	100%	27.86	1 / 1
peripheral blood	100%	7996.78	928 / 929	0%	0	0 / 0
blood vessel	100%	3808.39	1333 / 1335	0%	0	0 / 0
heart	100%	4924.69	857 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0072513	Biological process	positive regulation of secondary heart field cardioblast proliferation
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_2000179	Biological process	positive regulation of neural precursor cell proliferation
GO_0005834	Cellular component	heterotrimeric G-protein complex
GO_0070062	Cellular component	extracellular exosome
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0030165	Molecular function	PDZ domain binding
GO_0031681	Molecular function	G-protein beta-subunit binding
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

Gene name	GNG5
Protein name	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Synonyms	GNGT5
Description	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Accessions	ENST00000370641.3 ENST00000370645.9 ENST00000686161.1 P63218

GNG5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review