RGS7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901381Biological processpositive regulation of potassium ion transmembrane transport
GO_0001975Biological processresponse to amphetamine
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_0045471Biological processresponse to ethanol
GO_0043547Biological processpositive regulation of GTPase activity
GO_0045744Biological processnegative regulation of G protein-coupled receptor signaling pathway
GO_0005635Cellular componentnuclear envelope
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0043005Cellular componentneuron projection
GO_0005737Cellular componentcytoplasm
GO_0031681Molecular functionG-protein beta-subunit binding
GO_0001965Molecular functionG-protein alpha-subunit binding
GO_0005096Molecular functionGTPase activator activity
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRGS7
Protein nameRegulator of G-protein signaling 7 (RGS7)
Regulator of G-protein signaling 7 isoform A
Regulator of G protein signaling 7
Regulator of G-protein-signaling 7
Regulator of G protein signaling 7 (cDNA FLJ61685, highly similar to Regulator of G-protein signaling 7)
Regulator of G-protein signaling 7 isoform D
Synonyms
DescriptionFUNCTION: GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades . The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form . May play a role in synaptic vesicle exocytosis (Probable). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling . .

AccessionsENST00000688633.1
ENST00000689602.1
A0A8I5KXV8
Q5T3H5
ENST00000686465.1
ENST00000686908.1
A0A8I5QJE1
B7Z257
A0A8I5KV90
ENST00000688737.1
A0A8I5KR27
A0A8I5KXW5
A0A8I5KY39
ENST00000687018.1
ENST00000686340.1
A0A8I5KUA7
ENST00000689640.1
A0A8I5QJ89
ENST00000366564.5 [P49802-2]
ENST00000687040.1
A0A8I5KZ50
A0A8I5KVW2
ENST00000348120.6 [P49802-4]
A0A8I5KRH6
ENST00000366563.5 [P49802-3]
ENST00000687448.1
ENST00000691989.1
P49802
ENST00000688863.1
Q45FE0
ENST00000691485.1
ENST00000685936.1
ENST00000689115.1
ENST00000690356.1
ENST00000688703.1
ENST00000440928
A0A8I5KY47
Q45FD9
A0A8I5KRS1
A0A8I5QKX5
ENST00000692410.1
ENST00000691979.1 [P49802-3]
ENST00000690614.1
ENST00000693043.1 [P49802-4]
ENST00000690019.1
A0A8I5KZ23
A0A8I5QJU0
ENST00000688545.1
ENST00000690539.1
ENST00000440928.6 [P49802-1]
ENST00000366565.5 [P49802-5]