Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte precursor cell | 14 studies | 60% ± 21% | |
astrocyte | 14 studies | 51% ± 18% | |
glutamatergic neuron | 12 studies | 82% ± 14% | |
GABAergic neuron | 11 studies | 68% ± 26% | |
neuron | 7 studies | 52% ± 20% | |
oligodendrocyte | 7 studies | 35% ± 20% | |
interneuron | 6 studies | 77% ± 17% | |
retina horizontal cell | 6 studies | 67% ± 31% | |
endothelial cell | 5 studies | 50% ± 19% | |
microglial cell | 5 studies | 42% ± 22% | |
amacrine cell | 5 studies | 57% ± 27% | |
granule cell | 4 studies | 78% ± 17% | |
retinal bipolar neuron | 4 studies | 47% ± 30% | |
retinal ganglion cell | 4 studies | 65% ± 23% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 49% ± 2% | |
GABAergic interneuron | 3 studies | 79% ± 13% | |
GABAergic amacrine cell | 3 studies | 47% ± 11% | |
OFF-bipolar cell | 3 studies | 48% ± 5% | |
ON-bipolar cell | 3 studies | 51% ± 8% | |
glycinergic amacrine cell | 3 studies | 78% ± 2% | |
rod bipolar cell | 3 studies | 79% ± 28% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 97% | 2422.72 | 2558 / 2642 | 91% | 10.41 | 640 / 705 |
adrenal gland | 43% | 167.34 | 111 / 258 | 77% | 10.37 | 176 / 230 |
pancreas | 0% | 0 | 0 / 328 | 38% | 1.14 | 67 / 178 |
kidney | 8% | 26.91 | 7 / 89 | 19% | 0.98 | 171 / 901 |
stomach | 3% | 7.03 | 9 / 359 | 13% | 0.49 | 37 / 286 |
lymph node | 0% | 0 | 0 / 0 | 14% | 0.48 | 4 / 29 |
lung | 0% | 0 | 0 / 578 | 12% | 0.55 | 137 / 1155 |
uterus | 0% | 0 | 0 / 170 | 11% | 0.47 | 49 / 459 |
ovary | 4% | 14.98 | 7 / 180 | 6% | 0.16 | 25 / 430 |
intestine | 0% | 0.23 | 1 / 966 | 9% | 0.28 | 47 / 527 |
breast | 0% | 0 | 0 / 459 | 8% | 0.48 | 94 / 1118 |
esophagus | 0% | 0 | 0 / 1445 | 8% | 0.41 | 15 / 183 |
skin | 4% | 11.24 | 64 / 1809 | 4% | 0.20 | 21 / 472 |
bladder | 0% | 0 | 0 / 21 | 4% | 0.22 | 20 / 504 |
liver | 2% | 8.36 | 5 / 226 | 1% | 0.05 | 4 / 406 |
eye | 0% | 0 | 0 / 0 | 3% | 0.10 | 2 / 80 |
thymus | 0% | 0 | 0 / 653 | 2% | 0.06 | 12 / 605 |
prostate | 0% | 0 | 0 / 245 | 1% | 0.01 | 5 / 502 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
adipose | 0% | 0 | 0 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 0% | 0 | 0 / 1335 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_1901381 | Biological process | positive regulation of potassium ion transmembrane transport |
GO_0001975 | Biological process | response to amphetamine |
GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0008277 | Biological process | regulation of G protein-coupled receptor signaling pathway |
GO_0045471 | Biological process | response to ethanol |
GO_0043547 | Biological process | positive regulation of GTPase activity |
GO_0045744 | Biological process | negative regulation of G protein-coupled receptor signaling pathway |
GO_0005635 | Cellular component | nuclear envelope |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0043005 | Cellular component | neuron projection |
GO_0005737 | Cellular component | cytoplasm |
GO_0031681 | Molecular function | G-protein beta-subunit binding |
GO_0001965 | Molecular function | G-protein alpha-subunit binding |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0003924 | Molecular function | GTPase activity |
Gene name | RGS7 |
Protein name | Regulator of G-protein signaling 7 (RGS7) Regulator of G-protein signaling 7 isoform A Regulator of G protein signaling 7 Regulator of G-protein-signaling 7 Regulator of G protein signaling 7 (cDNA FLJ61685, highly similar to Regulator of G-protein signaling 7) Regulator of G-protein signaling 7 isoform D |
Synonyms | |
Description | FUNCTION: GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades . The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form . May play a role in synaptic vesicle exocytosis (Probable). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling . . |
Accessions | ENST00000688633.1 ENST00000689602.1 A0A8I5KXV8 Q5T3H5 ENST00000686465.1 ENST00000686908.1 A0A8I5QJE1 B7Z257 A0A8I5KV90 ENST00000688737.1 A0A8I5KR27 A0A8I5KXW5 A0A8I5KY39 ENST00000687018.1 ENST00000686340.1 A0A8I5KUA7 ENST00000689640.1 A0A8I5QJ89 ENST00000366564.5 [P49802-2] ENST00000687040.1 A0A8I5KZ50 A0A8I5KVW2 ENST00000348120.6 [P49802-4] A0A8I5KRH6 ENST00000366563.5 [P49802-3] ENST00000687448.1 ENST00000691989.1 P49802 ENST00000688863.1 Q45FE0 ENST00000691485.1 ENST00000685936.1 ENST00000689115.1 ENST00000690356.1 ENST00000688703.1 ENST00000440928 A0A8I5KY47 Q45FD9 A0A8I5KRS1 A0A8I5QKX5 ENST00000692410.1 ENST00000691979.1 [P49802-3] ENST00000690614.1 ENST00000693043.1 [P49802-4] ENST00000690019.1 A0A8I5KZ23 A0A8I5QJU0 ENST00000688545.1 ENST00000690539.1 ENST00000440928.6 [P49802-1] ENST00000366565.5 [P49802-5] |