GPR75 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPR75 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR75 at tissue level.

III. Associated gene sets

GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0070098Biological processchemokine-mediated signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0016493Molecular functionC-C chemokine receptor activity
GO_0004930Molecular functionG protein-coupled receptor activity

IV. Literature review

[source]
Gene nameGPR75
Protein nameProbable G-protein coupled receptor 75
Synonyms
DescriptionFUNCTION: G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. .

AccessionsENST00000394705.3
O95800