HCAR3 | OmnibusX

Name	Number of supported studies	Average coverage
neutrophil	3 studies	29% ± 6%	Explore
basal cell	3 studies	24% ± 9%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of HCAR3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	75%	168.61	431 / 578	56%	2.94	650 / 1155
bladder	43%	75.43	9 / 21	66%	4.66	334 / 504
spleen	99%	350.98	238 / 241	0%	0	0 / 0
peripheral blood	95%	2233.47	881 / 929	0%	0	0 / 0
esophagus	37%	120.42	533 / 1445	57%	3.38	105 / 183
tonsil	0%	0	0 / 0	91%	13.80	41 / 45
breast	65%	53.28	300 / 459	13%	0.22	149 / 1118
skin	70%	210.87	1267 / 1809	5%	0.12	25 / 472
uterus	2%	2.79	4 / 170	54%	5.36	249 / 459
adipose	54%	51.86	646 / 1204	0%	0	0 / 0
prostate	26%	26.40	64 / 245	9%	0.19	46 / 502
kidney	24%	15.72	21 / 89	8%	0.36	68 / 901
stomach	3%	3.03	12 / 359	27%	1.40	77 / 286
intestine	2%	2.22	24 / 966	26%	1.05	137 / 527
liver	15%	9.10	34 / 226	8%	0.22	31 / 406
lymph node	0%	0	0 / 0	21%	0.54	6 / 29
pancreas	0%	0	0 / 328	17%	1.27	30 / 178
thymus	4%	2.34	26 / 653	9%	0.40	53 / 605
ovary	0%	0	0 / 180	4%	0.09	18 / 430
heart	4%	3.31	32 / 861	0%	0	0 / 0
blood vessel	4%	2.39	49 / 1335	0%	0	0 / 0
brain	0%	0.16	8 / 2642	2%	0.03	13 / 705
adrenal gland	0%	0	0 / 258	1%	0.02	2 / 230
muscle	0%	0.06	1 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

Gene name	HCAR3
Protein name	Hydroxycarboxylic acid receptor 3 (G-protein coupled receptor 109B) (G-protein coupled receptor HM74) (G-protein coupled receptor HM74B) (Niacin receptor 2) (Nicotinic acid receptor 2) Hydroxycarboxylic acid receptor 3
Synonyms	HCA3 HM74B GPR109B NIACR2
Description	FUNCTION: Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. .
Accessions	ENST00000528880.3 P49019 A0A4Y1JWR6

GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0030054	Cellular component	cell junction
GO_0005886	Cellular component	plasma membrane
GO_0070553	Molecular function	nicotinic acid receptor activity
GO_0004930	Molecular function	G protein-coupled receptor activity

HCAR3 report