GPR161 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901621Biological processnegative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0060170Cellular componentciliary membrane
GO_0097386Cellular componentglial cell projection
GO_0005929Cellular componentcilium
GO_0005886Cellular componentplasma membrane
GO_0043005Cellular componentneuron projection
GO_0055037Cellular componentrecycling endosome
GO_0030666Cellular componentendocytic vesicle membrane
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPR161
Protein nameG-protein coupled receptor 161 (G-protein coupled receptor RE2)
G protein-coupled receptor 161
SynonymshCG_42392
DescriptionFUNCTION: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity). .

AccessionsENST00000546300.5 [Q8N6U8-5]
ENST00000271357.9
ENST00000367838.5 [Q8N6U8-1]
A0A0A0MQW8
ENST00000367835.1 [Q8N6U8-1]
ENST00000539777.5 [Q8N6U8-4]
ENST00000367836.5 [Q8N6U8-3]
ENST00000537209.5 [Q8N6U8-6]
ENST00000682931.1 [Q8N6U8-1]
Q8N6U8