ADGRG1 | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	27 studies	36% ± 12%	Explore
astrocyte	18 studies	35% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	51% ± 17%	Explore
endothelial cell	14 studies	22% ± 4%	Explore
mature NK T cell	11 studies	35% ± 11%	Explore
gamma-delta T cell	11 studies	27% ± 8%	Explore
oligodendrocyte precursor cell	10 studies	41% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	25% ± 8%	Explore
CD8-positive, alpha-beta T cell	8 studies	29% ± 7%	Explore
microglial cell	8 studies	38% ± 11%	Explore
basal cell	7 studies	24% ± 8%	Explore
epithelial cell	7 studies	31% ± 12%	Explore
endothelial cell of vascular tree	7 studies	23% ± 6%	Explore
vein endothelial cell	5 studies	22% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	28% ± 6%	Explore
ciliated cell	4 studies	21% ± 5%	Explore
secretory cell	4 studies	24% ± 4%	Explore
kidney loop of Henle epithelial cell	4 studies	27% ± 7%	Explore
capillary endothelial cell	4 studies	23% ± 7%	Explore
endothelial cell of artery	4 studies	20% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	38% ± 21%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	47% ± 3%	Explore
abnormal cell	3 studies	34% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	26% ± 10%	Explore
melanocyte	3 studies	29% ± 10%	Explore
goblet cell	3 studies	24% ± 1%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	20% ± 3%	Explore
double negative thymocyte	3 studies	34% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
kidney	4 studies	21% ± 3%	Explore
brain	4 studies	31% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	22339.09	653 / 653	98%	248.80	590 / 605
pancreas	100%	5357.85	328 / 328	96%	94.14	170 / 178
brain	96%	10289.94	2548 / 2642	99%	288.70	696 / 705
kidney	100%	27213.08	89 / 89	92%	142.19	833 / 901
breast	100%	9328.19	459 / 459	86%	63.75	961 / 1118
lung	99%	6896.18	571 / 578	86%	76.99	992 / 1155
bladder	90%	5069.67	19 / 21	90%	89.57	455 / 504
prostate	96%	6305.08	235 / 245	83%	44.85	416 / 502
stomach	91%	6039.71	328 / 359	87%	81.97	248 / 286
uterus	95%	3692.95	162 / 170	81%	77.66	373 / 459
esophagus	80%	4130.04	1152 / 1445	96%	109.88	176 / 183
skin	73%	10168.63	1312 / 1809	93%	270.29	438 / 472
intestine	70%	2581.45	678 / 966	94%	92.70	495 / 527
ovary	16%	401.89	28 / 180	92%	91.44	396 / 430
ureter	0%	0	0 / 0	100%	50.69	1 / 1
adipose	100%	7444.00	1203 / 1204	0%	0	0 / 0
adrenal gland	78%	2178.88	202 / 258	14%	11.06	32 / 230
tonsil	0%	0	0 / 0	87%	59.84	39 / 45
eye	0%	0	0 / 0	86%	147.83	69 / 80
heart	81%	2534.93	700 / 861	0%	0	0 / 0
peripheral blood	48%	3808.63	443 / 929	0%	0	0 / 0
spleen	41%	1032.67	100 / 241	0%	0	0 / 0
blood vessel	36%	1018.23	475 / 1335	0%	0	0 / 0
muscle	23%	481.41	183 / 803	0%	0	0 / 0
liver	1%	22.31	2 / 226	15%	13.53	61 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010573	Biological process	vascular endothelial growth factor production
GO_0001525	Biological process	angiogenesis
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0061351	Biological process	neural precursor cell proliferation
GO_0021819	Biological process	layer formation in cerebral cortex
GO_0007155	Biological process	cell adhesion
GO_0045785	Biological process	positive regulation of cell adhesion
GO_0072520	Biological process	seminiferous tubule development
GO_0061484	Biological process	hematopoietic stem cell homeostasis
GO_0007267	Biological process	cell-cell signaling
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_2000179	Biological process	positive regulation of neural precursor cell proliferation
GO_0021796	Biological process	cerebral cortex regionalization
GO_0007189	Biological process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0007420	Biological process	brain development
GO_0007266	Biological process	Rho protein signal transduction
GO_0070528	Biological process	protein kinase C signaling
GO_0035025	Biological process	positive regulation of Rho protein signal transduction
GO_0016477	Biological process	cell migration
GO_0021801	Biological process	cerebral cortex radial glia-guided migration
GO_2001223	Biological process	negative regulation of neuron migration
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0005886	Cellular component	plasma membrane
GO_0045121	Cellular component	membrane raft
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0097451	Cellular component	glial limiting end-foot
GO_0008201	Molecular function	heparin binding
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0050840	Molecular function	extracellular matrix binding
GO_0005518	Molecular function	collagen binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ADGRG1
Protein name	Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) Adhesion G protein-coupled receptor G1 Adhesion G-protein coupled receptor G1 Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) (Protein TM7XN1) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
Synonyms	TM7XN1 UNQ540/PRO1083 GPR56 TM7LN4
Description	FUNCTION: Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 . Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA . Plays an essential role in testis development (By similarity). .; FUNCTION: [ADGRG1 N-terminal fragment]: Plays a critical role in cancer progression by activating VEGFA production and angiogenesis through a signaling pathway mediated by PRKCA . .
Accessions	ENST00000562631.7 [Q9Y653-2] H3BSP5 H3BMC2 ENST00000563374.5 ENST00000568618.5 ENST00000563862.5 ENST00000564729.5 Q9Y653 H3BV72 ENST00000565976.6 [Q9Y653-1] H3BSF7 ENST00000568979.5 H3BRH0 A0A5F9ZH94 H3BVD3 ENST00000563414.5 ENST00000570044.5 ENST00000561696.5 ENST00000564722.5 ENST00000567154.5 ENST00000561988.5 H3BS54 ENST00000569494.5 ENST00000569101.5 H3BV52 H3BQJ9 H3BMF8 H3BPC0 ENST00000563445.5 H3BSN7 ENST00000568157.5 ENST00000566169.5 ENST00000565338.5 ENST00000564360.5 ENST00000565770.5 ENST00000456916.5 [Q9Y653-3] ENST00000568234.5 ENST00000568908.5 [Q9Y653-2] ENST00000565976 H3BUF5 ENST00000388813.9 [Q9Y653-2] H3BSJ6 ENST00000566778.5 ENST00000673126 H3BQW4 ENST00000568074.5 ENST00000567397.5 ENST00000565539.5 ENST00000673126.2 [Q9Y653-1] H3BNH4 ENST00000566123.5 ENST00000561833.5 H3BT88 ENST00000563548.5 H3BQZ1 ENST00000566187.1 ENST00000566164.5 H3BPA6 ENST00000566271.6 ENST00000562682.5 H3BV84 A0A1B0GX62 H3BS98 ENST00000566508.5 ENST00000565013.5 ENST00000540164.6 [Q9Y653-2] ENST00000568645.5 H3BP94 H3BSN3 H3BQ11 ENST00000568909.5 [Q9Y653-1] ENST00000561969.5 ENST00000565391.1 H3BM73 A0A5F9ZHT7 ENST00000569154.5 H3BS94 H3BQ46 ENST00000567915.5 ENST00000565314.5 ENST00000568531.5 ENST00000569158.5 ENST00000562003.5 H3BTK9 H3BNN3 H3BMY9 H3BVA0 H3BTD2 H3BRZ4 ENST00000564103.5 H3BRB4 H3BUH2 ENST00000565587.5 H3BVE9 ENST00000569531.5 ENST00000562467.5 H3BSB8 ENST00000672974.1 H3BRA1 ENST00000563007.5 H3BUU6 H3BP67 H3BTH7 A0A024R6U7 H3BS14 A0A0S2Z517 ENST00000567702.5 ENST00000562414.5 ENST00000568791.5 ENST00000562558.6 [Q9Y653-2] H3BRI2 ENST00000569372.5 H3BSR1 ENST00000564907.5 ENST00000561782.5 ENST00000567553.5 ENST00000567835.5 [Q9Y653-1] H3BRI7

ADGRG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review