GRK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0031623Biological processreceptor internalization
GO_0007213Biological processG protein-coupled acetylcholine receptor signaling pathway
GO_0002029Biological processdesensitization of G protein-coupled receptor signaling pathway
GO_0007507Biological processheart development
GO_0007217Biological processtachykinin receptor signaling pathway
GO_1901081Biological processnegative regulation of relaxation of smooth muscle
GO_0002026Biological processregulation of the force of heart contraction
GO_0003108Biological processnegative regulation of the force of heart contraction by chemical signal
GO_0060048Biological processcardiac muscle contraction
GO_0046718Biological processsymbiont entry into host cell
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0045988Biological processnegative regulation of striated muscle contraction
GO_0033605Biological processpositive regulation of catecholamine secretion
GO_0006468Biological processprotein phosphorylation
GO_0019079Biological processviral genome replication
GO_0098793Cellular componentpresynapse
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0098794Cellular componentpostsynapse
GO_0005929Cellular componentcilium
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0004672Molecular functionprotein kinase activity
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0004703Molecular functionG protein-coupled receptor kinase activity
GO_0047696Molecular functionbeta-adrenergic receptor kinase activity
GO_0031694Molecular functionalpha-2A adrenergic receptor binding
GO_0031755Molecular functionEdg-2 lysophosphatidic acid receptor binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGRK2
Protein nameBeta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)
G protein-coupled receptor kinase (EC 2.7.11.-)
SynonymsBARK1
ADRBK1
BARK
DescriptionFUNCTION: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them . Key regulator of LPAR1 signaling . Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor . Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner . Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light . .

AccessionsE9PRV7
ENST00000526285.1
P25098
A0A0S2Z3I6
ENST00000308595.10
A0A0S2Z392