I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| plasma cell | 3 studies | 24% ± 3% | |
| GABAergic neuron | 3 studies | 24% ± 9% | |
| glutamatergic neuron | 3 studies | 26% ± 7% | |
| astrocyte | 3 studies | 37% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| plasma cell | 3 studies | 24% ± 3% | |
| GABAergic neuron | 3 studies | 24% ± 9% | |
| glutamatergic neuron | 3 studies | 26% ± 7% | |
| astrocyte | 3 studies | 37% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 25% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 24396.07 | 653 / 653 | 97% | 173.03 | 586 / 605 |
| brain | 74% | 38.95 | 1958 / 2642 | 48% | 3.39 | 337 / 705 |
| adrenal gland | 99% | 61.56 | 255 / 258 | 7% | 0.20 | 15 / 230 |
| spleen | 100% | 101.63 | 240 / 241 | 0% | 0 | 0 / 0 |
| breast | 96% | 51.73 | 441 / 459 | 2% | 0.05 | 26 / 1118 |
| liver | 98% | 34.51 | 222 / 226 | 0% | 0 | 0 / 406 |
| uterus | 88% | 43.67 | 150 / 170 | 3% | 0.14 | 16 / 459 |
| adipose | 90% | 44.81 | 1081 / 1204 | 0% | 0 | 0 / 0 |
| prostate | 89% | 51.58 | 217 / 245 | 1% | 0.04 | 4 / 502 |
| ovary | 69% | 14.06 | 125 / 180 | 12% | 0.55 | 51 / 430 |
| skin | 71% | 22.21 | 1283 / 1809 | 1% | 0.06 | 7 / 472 |
| stomach | 69% | 16.07 | 247 / 359 | 2% | 0.03 | 5 / 286 |
| kidney | 63% | 14.99 | 56 / 89 | 6% | 0.10 | 53 / 901 |
| intestine | 68% | 22.16 | 653 / 966 | 1% | 0.01 | 3 / 527 |
| lung | 60% | 18.39 | 346 / 578 | 3% | 0.14 | 31 / 1155 |
| esophagus | 56% | 12.29 | 814 / 1445 | 2% | 0.02 | 3 / 183 |
| bladder | 52% | 16.71 | 11 / 21 | 2% | 0.04 | 10 / 504 |
| pancreas | 49% | 14.99 | 161 / 328 | 1% | 0.01 | 2 / 178 |
| heart | 45% | 8.27 | 390 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 44% | 12.03 | 411 / 929 | 0% | 0 | 0 / 0 |
| muscle | 33% | 6.95 | 264 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 29% | 6.56 | 387 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.10 | 2 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.03 | 1 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0038194 | Biological process | thyroid-stimulating hormone signaling pathway |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0007190 | Biological process | activation of adenylate cyclase activity |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_1905229 | Biological process | cellular response to thyrotropin-releasing hormone |
| GO_1904588 | Biological process | cellular response to glycoprotein |
| GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
| GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO_0009755 | Biological process | hormone-mediated signaling pathway |
| GO_0007187 | Biological process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0009986 | Cellular component | cell surface |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0008528 | Molecular function | G protein-coupled peptide receptor activity |
| GO_0004996 | Molecular function | thyroid-stimulating hormone receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TSHR |
| Protein name | Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R) TSH receptor Thyrotropin receptor TSHR protein (Thyroid stimulating hormone receptor) Thyroid stimulating hormone receptor |
| Synonyms | LGR3 |
| Description | FUNCTION: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin . Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin . The activity of this receptor is mediated by G proteins which activate adenylate cyclase . Plays a central role in controlling thyroid cell metabolism (By similarity). . FUNCTION: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. . FUNCTION: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. . FUNCTION: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. . FUNCTION: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. . FUNCTION: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. . FUNCTION: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. . FUNCTION: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. . |
| Accessions | B4E0H2 ENST00000554435.1 [P16473-3] Q8NH23 ENST00000555326.5 ENST00000637447.1 ENST00000642209.1 A0A1B0RYB7 A0A2R8Y709 A0A1B0RYB9 ENST00000298171.7 Q0VAP8 A0A1B0GUJ5 ENST00000554263.5 ENST00000541158.6 A0A0A0MTJ0 ENST00000342443.10 [P16473-2] G3V381 O43200 P16473 Q59GA2 |
