OR2AT4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of OR2AT4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OR2AT4 at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0050911Biological processdetection of chemical stimulus involved in sensory perception of smell
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0005886Cellular componentplasma membrane
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0004984Molecular functionolfactory receptor activity

IV. Literature review

[source]
Gene nameOR2AT4
Protein nameOlfactory receptor 2AT4 (Olfactory receptor OR11-265)
Olfactory receptor
Synonyms
DescriptionFUNCTION: Olfactory receptor . Activated by the synthetic sandalwood odorant sandalore . Endogenous ligand is unknown (Probable). The activity of this receptor is probably mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs . Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes . Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases . .

AccessionsENST00000641593.1
A0A126GWB1
ENST00000641504.1
A6NND4
ENST00000305159.3
ENST00000641931.1
ENST00000641541.1