AKR1C3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016488Biological processfarnesol catabolic process
GO_0007584Biological processresponse to nutrient
GO_0044597Biological processdaunorubicin metabolic process
GO_0030216Biological processkeratinocyte differentiation
GO_0071799Biological processcellular response to prostaglandin D stimulus
GO_1900053Biological processnegative regulation of retinoic acid biosynthetic process
GO_0019371Biological processcyclooxygenase pathway
GO_0048385Biological processregulation of retinoic acid receptor signaling pathway
GO_0044598Biological processdoxorubicin metabolic process
GO_0071395Biological processcellular response to jasmonic acid stimulus
GO_2000224Biological processregulation of testosterone biosynthetic process
GO_0042448Biological processprogesterone metabolic process
GO_0071384Biological processcellular response to corticosteroid stimulus
GO_0061370Biological processtestosterone biosynthetic process
GO_0009267Biological processcellular response to starvation
GO_0071277Biological processcellular response to calcium ion
GO_0001523Biological processretinoid metabolic process
GO_0070293Biological processrenal absorption
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0042574Biological processretinal metabolic process
GO_2000379Biological processpositive regulation of reactive oxygen species metabolic process
GO_0071379Biological processcellular response to prostaglandin stimulus
GO_0042572Biological processretinol metabolic process
GO_0006693Biological processprostaglandin metabolic process
GO_0008584Biological processmale gonad development
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0043170Biological processmacromolecule metabolic process
GO_0008202Biological processsteroid metabolic process
GO_2000353Biological processpositive regulation of endothelial cell apoptotic process
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0047024Molecular function5alpha-androstane-3beta,17beta-diol dehydrogenase activity
GO_0047086Molecular functionketosteroid monooxygenase activity
GO_0018636Molecular functionphenanthrene 9,10-monooxygenase activity
GO_0004032Molecular functionaldose reductase (NADPH) activity
GO_0047044Molecular functionandrostan-3-alpha,17-beta-diol dehydrogenase activity
GO_0016655Molecular functionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO_0047023Molecular functionandrosterone dehydrogenase activity
GO_0045703Molecular functionketoreductase activity
GO_0036131Molecular functionprostaglandin D2 11-ketoreductase activity
GO_0004033Molecular functionaldo-keto reductase (NADPH) activity
GO_0047035Molecular functiontestosterone dehydrogenase (NAD+) activity
GO_0001758Molecular functionretinal dehydrogenase activity
GO_0036130Molecular functionprostaglandin H2 endoperoxidase reductase activity
GO_0052650Molecular functionall-trans-retinol dehydrogenase (NADP+) activity
GO_0032052Molecular functionbile acid binding
GO_0047017Molecular functionprostaglandin F synthase activity
GO_0047045Molecular functiontestosterone 17-beta-dehydrogenase (NADP+) activity
GO_0004303Molecular functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO_0047787Molecular functionDelta4-3-oxosteroid 5beta-reductase activity
GO_0045550Molecular functiongeranylgeranyl reductase activity
GO_0004745Molecular functionall-trans-retinol dehydrogenase (NAD+) activity
GO_0035410Molecular functiondihydrotestosterone 17-beta-dehydrogenase activity
GO_0047020Molecular function15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

IV. Literature review

[source]
Gene nameAKR1C3
Protein nameAldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64)
Aldo-keto reductase family 1 member C3 (Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II), isoform CRA_a)
Aldo-keto reductase family 1 member C3
SynonymsPGFS
KIAA0119
DDH1
hCG_19343
HSD17B5
DescriptionFUNCTION: Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone . Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH . Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone . Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol . Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) . Also displays retinaldehyde reductase activity toward 9-cis-retinal . .

AccessionsENST00000439082.7
ENST00000605149.5
S4R3Z2
P42330
A0A0A0MSS8
ENST00000602997.5
ENST00000380554.5 [P42330-1]
S4R3D5