| Name | Delta4-3-oxosteroid 5beta-reductase activity |
| ID | GO_0047787 |
| collection_id | Molecular function |
| Alternative ID | GO:0047752 |
| Exact synonym | 3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity, 3-oxo-Delta(4)-steroid 5-beta-reductase activity, 3-oxo-Delta4-steroid 5beta-reductase activity, Delta4-3-oxosteroid 5-beta-reductase activity |
| Description | Catalysis of the reaction: a 3-oxo-5beta-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + H+ + NADPH. The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent. The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3- one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates. |
| Related synonym | 5beta-reductase activity, Delta(4)-3-ketosteroid 5-beta-reductase activity, Delta(4)-5-beta-reductase activity, Delta(4)-hydrogenase activity, Delta4-3-ketosteroid 5beta-reductase activity, Delta4-5beta-reductase activity, Delta4-hydrogenase activity, cortisone delta4-5beta-reductase activity, steroid 5-beta-reductase activity, steroid 5beta-reductase activity |
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| Genes |