AKR1D1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of AKR1D1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AKR1D1 at tissue level.

III. Associated gene sets

GO_0006707Biological processcholesterol catabolic process
GO_0006699Biological processbile acid biosynthetic process
GO_0008209Biological processandrogen metabolic process
GO_0030573Biological processbile acid catabolic process
GO_0008207Biological processC21-steroid hormone metabolic process
GO_0007586Biological processdigestion
GO_0005829Cellular componentcytosol
GO_0016229Molecular functionsteroid dehydrogenase activity
GO_0047787Molecular functionDelta4-3-oxosteroid 5beta-reductase activity
GO_0047086Molecular functionketosteroid monooxygenase activity
GO_0004033Molecular functionaldo-keto reductase (NADPH) activity
GO_0004032Molecular functionaldose reductase (NADPH) activity
GO_0005496Molecular functionsteroid binding

IV. Literature review

[source]
Gene nameAKR1D1
Protein nameAldo-keto reductase family 1 member D1
Aldo-keto reductase family 1, member D1 (EC 1.3.99.6)
Aldo-keto reductase family 1 member D1 (EC 1.3.1.3) (3-oxo-5-beta-steroid 4-dehydrogenase) (Delta(4)-3-ketosteroid 5-beta-reductase) (Delta(4)-3-oxosteroid 5-beta-reductase)
SynonymsSRD5B1
DescriptionFUNCTION: Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one). .

AccessionsENST00000242375.8 [P51857-1]
ENST00000432161.5 [P51857-2]
C4PL37
P51857
ENST00000411726.6 [P51857-3]
C4PL36
C9J3U1
C4PL35
ENST00000438242.1