Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 31 studies | 45% ± 21% | |
classical monocyte | 25 studies | 44% ± 25% | |
conventional dendritic cell | 19 studies | 34% ± 19% | |
monocyte | 18 studies | 44% ± 15% | |
basal cell | 15 studies | 42% ± 23% | |
neutrophil | 13 studies | 65% ± 22% | |
dendritic cell | 9 studies | 40% ± 15% | |
non-classical monocyte | 9 studies | 47% ± 26% | |
myeloid cell | 9 studies | 49% ± 26% | |
secretory cell | 9 studies | 56% ± 26% | |
fibroblast | 8 studies | 34% ± 20% | |
endothelial cell | 6 studies | 34% ± 20% | |
leukocyte | 6 studies | 44% ± 24% | |
epithelial cell | 6 studies | 68% ± 21% | |
endothelial cell of lymphatic vessel | 5 studies | 26% ± 13% | |
mononuclear phagocyte | 5 studies | 49% ± 22% | |
ciliated cell | 5 studies | 43% ± 20% | |
smooth muscle cell | 5 studies | 34% ± 14% | |
pericyte | 5 studies | 38% ± 18% | |
endothelial cell of vascular tree | 5 studies | 50% ± 20% | |
natural killer cell | 4 studies | 25% ± 10% | |
club cell | 4 studies | 39% ± 19% | |
intermediate monocyte | 4 studies | 43% ± 22% | |
alveolar macrophage | 3 studies | 27% ± 5% | |
monocyte-derived dendritic cell | 3 studies | 73% ± 12% | |
inflammatory macrophage | 3 studies | 69% ± 23% | |
respiratory goblet cell | 3 studies | 46% ± 16% | |
luminal cell of prostate epithelium | 3 studies | 44% ± 5% | |
connective tissue cell | 3 studies | 40% ± 23% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 98% | 6182.44 | 568 / 578 | 82% | 148.06 | 948 / 1155 |
pancreas | 45% | 477.71 | 148 / 328 | 76% | 63.66 | 136 / 178 |
stomach | 35% | 466.08 | 125 / 359 | 82% | 199.86 | 234 / 286 |
intestine | 26% | 266.78 | 252 / 966 | 82% | 145.59 | 430 / 527 |
kidney | 75% | 716.01 | 67 / 89 | 26% | 15.34 | 230 / 901 |
esophagus | 17% | 143.32 | 239 / 1445 | 84% | 139.26 | 154 / 183 |
liver | 59% | 472.20 | 133 / 226 | 35% | 39.04 | 143 / 406 |
bladder | 19% | 590.48 | 4 / 21 | 67% | 147.32 | 338 / 504 |
uterus | 13% | 70.41 | 22 / 170 | 62% | 100.14 | 286 / 459 |
prostate | 56% | 662.45 | 136 / 245 | 19% | 7.71 | 95 / 502 |
tonsil | 0% | 0 | 0 / 0 | 73% | 57.02 | 33 / 45 |
ovary | 28% | 376.27 | 50 / 180 | 43% | 24.00 | 185 / 430 |
skin | 30% | 727.12 | 546 / 1809 | 38% | 24.16 | 177 / 472 |
thymus | 43% | 237.57 | 282 / 653 | 21% | 8.31 | 129 / 605 |
adipose | 62% | 1360.76 | 744 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 57% | 13042.00 | 534 / 929 | 0% | 0 | 0 / 0 |
adrenal gland | 40% | 613.86 | 103 / 258 | 11% | 7.38 | 25 / 230 |
breast | 36% | 238.68 | 163 / 459 | 15% | 7.13 | 167 / 1118 |
blood vessel | 48% | 403.22 | 639 / 1335 | 0% | 0 | 0 / 0 |
brain | 23% | 181.69 | 615 / 2642 | 23% | 34.09 | 162 / 705 |
heart | 45% | 1099.70 | 391 / 861 | 0% | 0 | 0 / 0 |
spleen | 33% | 368.69 | 79 / 241 | 0% | 0 | 0 / 0 |
muscle | 6% | 22.00 | 52 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 3% | 14.68 | 1 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0001525 | Biological process | angiogenesis |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0031623 | Biological process | receptor internalization |
GO_0006954 | Biological process | inflammatory response |
GO_0019722 | Biological process | calcium-mediated signaling |
GO_0010629 | Biological process | negative regulation of gene expression |
GO_0034976 | Biological process | response to endoplasmic reticulum stress |
GO_0045766 | Biological process | positive regulation of angiogenesis |
GO_0007165 | Biological process | signal transduction |
GO_0002237 | Biological process | response to molecule of bacterial origin |
GO_0048566 | Biological process | embryonic digestive tract development |
GO_0010628 | Biological process | positive regulation of gene expression |
GO_0030593 | Biological process | neutrophil chemotaxis |
GO_0071347 | Biological process | cellular response to interleukin-1 |
GO_0006935 | Biological process | chemotaxis |
GO_0031328 | Biological process | positive regulation of cellular biosynthetic process |
GO_0045744 | Biological process | negative regulation of G protein-coupled receptor signaling pathway |
GO_0071356 | Biological process | cellular response to tumor necrosis factor |
GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0070098 | Biological process | chemokine-mediated signaling pathway |
GO_0060354 | Biological process | negative regulation of cell adhesion molecule production |
GO_0071222 | Biological process | cellular response to lipopolysaccharide |
GO_0090023 | Biological process | positive regulation of neutrophil chemotaxis |
GO_0061844 | Biological process | antimicrobial humoral immune response mediated by antimicrobial peptide |
GO_0045091 | Biological process | regulation of single stranded viral RNA replication via double stranded DNA intermediate |
GO_0050930 | Biological process | induction of positive chemotaxis |
GO_0030155 | Biological process | regulation of cell adhesion |
GO_2000535 | Biological process | regulation of entry of bacterium into host cell |
GO_0044344 | Biological process | cellular response to fibroblast growth factor stimulus |
GO_0042119 | Biological process | neutrophil activation |
GO_0005615 | Cellular component | extracellular space |
GO_0005576 | Cellular component | extracellular region |
GO_0005153 | Molecular function | interleukin-8 receptor binding |
GO_0008201 | Molecular function | heparin binding |
GO_0008009 | Molecular function | chemokine activity |
GO_0045236 | Molecular function | CXCR chemokine receptor binding |
GO_0005515 | Molecular function | protein binding |
Gene name | CXCL8 |
Protein name | Multifunctional fusion protein [Includes: Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8); C-X-C motif chemokine] Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Neutrophil-activating protein 1) (NAP-1) (Protein 3-10C) (T-cell chemotactic factor) [Cleaved into: MDNCF-a (GCP/IL-8 protein IV) (IL8/NAP1 form I); Interleukin-8 ((Ala-IL-8)77) (GCP/IL-8 protein II) (IL-8(1-77)) (IL8/NAP1 form II) (MDNCF-b); IL-8(5-77); IL-8(6-77) ((Ser-IL-8)72) (GCP/IL-8 protein I) (IL8/NAP1 form III) (Lymphocyte-derived neutrophil-activating factor) (LYNAP) (MDNCF-c) (Neutrophil-activating factor) (NAF); IL-8(7-77) (GCP/IL-8 protein V) (IL8/NAP1 form IV); IL-8(8-77) (GCP/IL-8 protein VI) (IL8/NAP1 form V); IL-8(9-77) (GCP/IL-8 protein III) (IL8/NAP1 form VI)] Interleukin 8 C-X-C motif chemokine ligand 8 |
Synonyms | IL8 |
Description | FUNCTION: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection . Also plays an important role in neutrophil activation . Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells . G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways . . |
Accessions | P10145 ENST00000401931.1 C9J4T6 ENST00000307407.8 A0A7U3S0Q4 ENST00000696132.1 ENST00000696131.1 A0A8Q3SIG6 |