CXCL8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0031623Biological processreceptor internalization
GO_0006954Biological processinflammatory response
GO_0019722Biological processcalcium-mediated signaling
GO_0010629Biological processnegative regulation of gene expression
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0045766Biological processpositive regulation of angiogenesis
GO_0007165Biological processsignal transduction
GO_0002237Biological processresponse to molecule of bacterial origin
GO_0048566Biological processembryonic digestive tract development
GO_0010628Biological processpositive regulation of gene expression
GO_0030593Biological processneutrophil chemotaxis
GO_0071347Biological processcellular response to interleukin-1
GO_0006935Biological processchemotaxis
GO_0031328Biological processpositive regulation of cellular biosynthetic process
GO_0045744Biological processnegative regulation of G protein-coupled receptor signaling pathway
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0070098Biological processchemokine-mediated signaling pathway
GO_0060354Biological processnegative regulation of cell adhesion molecule production
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0090023Biological processpositive regulation of neutrophil chemotaxis
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0045091Biological processregulation of single stranded viral RNA replication via double stranded DNA intermediate
GO_0050930Biological processinduction of positive chemotaxis
GO_0030155Biological processregulation of cell adhesion
GO_2000535Biological processregulation of entry of bacterium into host cell
GO_0044344Biological processcellular response to fibroblast growth factor stimulus
GO_0042119Biological processneutrophil activation
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005153Molecular functioninterleukin-8 receptor binding
GO_0008201Molecular functionheparin binding
GO_0008009Molecular functionchemokine activity
GO_0045236Molecular functionCXCR chemokine receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCXCL8
Protein nameMultifunctional fusion protein [Includes: Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8); C-X-C motif chemokine]
Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Neutrophil-activating protein 1) (NAP-1) (Protein 3-10C) (T-cell chemotactic factor) [Cleaved into: MDNCF-a (GCP/IL-8 protein IV) (IL8/NAP1 form I); Interleukin-8 ((Ala-IL-8)77) (GCP/IL-8 protein II) (IL-8(1-77)) (IL8/NAP1 form II) (MDNCF-b); IL-8(5-77); IL-8(6-77) ((Ser-IL-8)72) (GCP/IL-8 protein I) (IL8/NAP1 form III) (Lymphocyte-derived neutrophil-activating factor) (LYNAP) (MDNCF-c) (Neutrophil-activating factor) (NAF); IL-8(7-77) (GCP/IL-8 protein V) (IL8/NAP1 form IV); IL-8(8-77) (GCP/IL-8 protein VI) (IL8/NAP1 form V); IL-8(9-77) (GCP/IL-8 protein III) (IL8/NAP1 form VI)]
Interleukin 8
C-X-C motif chemokine ligand 8
SynonymsIL8
DescriptionFUNCTION: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection . Also plays an important role in neutrophil activation . Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells . G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways . .

AccessionsP10145
ENST00000401931.1
C9J4T6
ENST00000307407.8
A0A7U3S0Q4
ENST00000696132.1
ENST00000696131.1
A0A8Q3SIG6