Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| vein endothelial cell | 10 studies | 29% ± 10% | |
| pericyte | 9 studies | 36% ± 11% | |
| macrophage | 7 studies | 26% ± 12% | |
| endothelial cell | 6 studies | 21% ± 5% | |
| hepatocyte | 6 studies | 55% ± 30% | |
| brush cell | 4 studies | 50% ± 20% | |
| myofibroblast cell | 3 studies | 32% ± 13% | |
| cholangiocyte | 3 studies | 50% ± 16% | |
| endothelial cell of artery | 3 studies | 20% ± 2% |
Insufficient scRNA-seq data for expression of ADGRG6 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 4563.40 | 226 / 226 | 85% | 22.54 | 347 / 406 |
| esophagus | 97% | 1399.53 | 1408 / 1445 | 87% | 27.39 | 160 / 183 |
| lung | 100% | 3581.46 | 578 / 578 | 78% | 14.30 | 904 / 1155 |
| bladder | 95% | 2258.29 | 20 / 21 | 80% | 18.74 | 403 / 504 |
| kidney | 89% | 764.03 | 79 / 89 | 83% | 26.69 | 752 / 901 |
| intestine | 100% | 1594.05 | 964 / 966 | 72% | 12.09 | 378 / 527 |
| stomach | 96% | 1286.00 | 346 / 359 | 73% | 14.04 | 209 / 286 |
| skin | 87% | 1819.03 | 1571 / 1809 | 66% | 18.09 | 311 / 472 |
| pancreas | 58% | 289.45 | 190 / 328 | 90% | 20.89 | 161 / 178 |
| breast | 92% | 727.46 | 421 / 459 | 48% | 6.95 | 541 / 1118 |
| prostate | 94% | 860.34 | 230 / 245 | 37% | 3.24 | 187 / 502 |
| uterus | 39% | 221.91 | 66 / 170 | 75% | 16.23 | 342 / 459 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.07 | 1 / 1 |
| adipose | 98% | 1499.09 | 1183 / 1204 | 0% | 0 | 0 / 0 |
| thymus | 79% | 584.06 | 516 / 653 | 14% | 2.57 | 82 / 605 |
| spleen | 83% | 641.00 | 201 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 13.56 | 37 / 45 |
| ovary | 28% | 166.89 | 51 / 180 | 39% | 4.59 | 168 / 430 |
| heart | 51% | 521.49 | 436 / 861 | 0% | 0 | 0 / 0 |
| adrenal gland | 36% | 157.71 | 94 / 258 | 6% | 0.43 | 14 / 230 |
| blood vessel | 41% | 287.71 | 547 / 1335 | 0% | 0 | 0 / 0 |
| brain | 13% | 66.49 | 340 / 2642 | 11% | 0.85 | 76 / 705 |
| muscle | 3% | 14.89 | 28 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 2.23 | 3 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0014037 | Biological process | Schwann cell differentiation |
| GO_0042552 | Biological process | myelination |
| GO_0060347 | Biological process | heart trabecula formation |
| GO_0019933 | Biological process | cAMP-mediated signaling |
| GO_0022011 | Biological process | myelination in peripheral nervous system |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO_0007399 | Biological process | nervous system development |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0009986 | Cellular component | cell surface |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0004175 | Molecular function | endopeptidase activity |
| GO_0004930 | Molecular function | G protein-coupled receptor activity |
| GO_0043236 | Molecular function | laminin binding |
| GO_0050840 | Molecular function | extracellular matrix binding |
| GO_0005518 | Molecular function | collagen binding |
| Gene name | ADGRG6 |
| Protein name | Adhesion G protein-coupled receptor G6 Adhesion G-protein coupled receptor G6 (Developmentally regulated G-protein-coupled receptor) (G-protein coupled receptor 126) (Vascular inducible G protein-coupled receptor) [Cleaved into: ADGRG6 N-terminal fragment (ADGRG6-NTF); ADGRG6 C-terminal fragment (ADGRG6-CTF)] |
| Synonyms | GPR126 DREG VIGR |
| Description | FUNCTION: G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins . Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons . Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity). . |
| Accessions | F5H2L1 Q86SQ4 ENST00000296932.13 [Q86SQ4-2] ENST00000508295.2 F5H054 ENST00000435011.6 ENST00000541199.5 ENST00000540208.1 H0YFM8 H0YGP2 ENST00000230173.10 [Q86SQ4-1] ENST00000367608.6 [Q86SQ4-4] ENST00000367609.8 [Q86SQ4-3] |
