INS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902952Biological processpositive regulation of dendritic spine maintenance
GO_0051247Biological processpositive regulation of protein metabolic process
GO_0010976Biological processpositive regulation of neuron projection development
GO_0046889Biological processpositive regulation of lipid biosynthetic process
GO_0046631Biological processalpha-beta T cell activation
GO_0007267Biological processcell-cell signaling
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0045922Biological processnegative regulation of fatty acid metabolic process
GO_0045861Biological processnegative regulation of proteolysis
GO_1900273Biological processpositive regulation of long-term synaptic potentiation
GO_0010750Biological processpositive regulation of nitric oxide mediated signal transduction
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0050708Biological processregulation of protein secretion
GO_0006006Biological processglucose metabolic process
GO_0042177Biological processnegative regulation of protein catabolic process
GO_0006953Biological processacute-phase response
GO_0010629Biological processnegative regulation of gene expression
GO_0038060Biological processnitric oxide-cGMP-mediated signaling
GO_0010628Biological processpositive regulation of gene expression
GO_0032880Biological processregulation of protein localization
GO_0090277Biological processpositive regulation of peptide hormone secretion
GO_0050709Biological processnegative regulation of protein secretion
GO_1903427Biological processnegative regulation of reactive oxygen species biosynthetic process
GO_0042060Biological processwound healing
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0045818Biological processnegative regulation of glycogen catabolic process
GO_0006355Biological processregulation of DNA-templated transcription
GO_0001819Biological processpositive regulation of cytokine production
GO_1903076Biological processregulation of protein localization to plasma membrane
GO_0060267Biological processpositive regulation of respiratory burst
GO_0045821Biological processpositive regulation of glycolytic process
GO_0033861Biological processnegative regulation of NAD(P)H oxidase activity
GO_0032148Biological processactivation of protein kinase B activity
GO_0055089Biological processfatty acid homeostasis
GO_0050714Biological processpositive regulation of protein secretion
GO_0045597Biological processpositive regulation of cell differentiation
GO_0008286Biological processinsulin receptor signaling pathway
GO_0046628Biological processpositive regulation of insulin receptor signaling pathway
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0042311Biological processvasodilation
GO_0060266Biological processnegative regulation of respiratory burst involved in inflammatory response
GO_0046326Biological processpositive regulation of glucose import
GO_0045721Biological processnegative regulation of gluconeogenesis
GO_0030307Biological processpositive regulation of cell growth
GO_1902176Biological processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO_1990535Biological processneuron projection maintenance
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0002674Biological processnegative regulation of acute inflammatory response
GO_0045725Biological processpositive regulation of glycogen biosynthetic process
GO_0048167Biological processregulation of synaptic plasticity
GO_0030335Biological processpositive regulation of cell migration
GO_0090336Biological processpositive regulation of brown fat cell differentiation
GO_0050995Biological processnegative regulation of lipid catabolic process
GO_0031954Biological processpositive regulation of protein autophosphorylation
GO_0050890Biological processcognition
GO_2000252Biological processnegative regulation of feeding behavior
GO_0051000Biological processpositive regulation of nitric-oxide synthase activity
GO_0006521Biological processregulation of cellular amino acid metabolic process
GO_0022898Biological processregulation of transmembrane transporter activity
GO_0045840Biological processpositive regulation of mitotic nuclear division
GO_0042593Biological processglucose homeostasis
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0031904Cellular componentendosome lumen
GO_0005576Cellular componentextracellular region
GO_0005615Cellular componentextracellular space
GO_0034774Cellular componentsecretory granule lumen
GO_0000139Cellular componentGolgi membrane
GO_0005796Cellular componentGolgi lumen
GO_0030133Cellular componenttransport vesicle
GO_0042802Molecular functionidentical protein binding
GO_0005179Molecular functionhormone activity
GO_0002020Molecular functionprotease binding
GO_0005515Molecular functionprotein binding
GO_0005158Molecular functioninsulin receptor binding
GO_0005159Molecular functioninsulin-like growth factor receptor binding

IV. Literature review

[source]
Gene nameINS
Protein nameInsulin [Cleaved into: Insulin B chain; Insulin A chain]
INS
Insulin
Synonyms
DescriptionFUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

FUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. .

FUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. .

FUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. .

AccessionsENST00000381330.5 [P01308-1]
ENST00000397262.5 [P01308-1]
A0A9E9AQX1
F6MZK5
C9JNR5
P01308
ENST00000250971.7 [P01308-1]
I3WAC9
A6XGL2
ENST00000512523.1
ENST00000421783.1