GPRC6A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPRC6A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPRC6A at tissue level.

III. Associated gene sets

GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0043200Biological processresponse to amino acid
GO_2000224Biological processregulation of testosterone biosynthetic process
GO_0005886Cellular componentplasma membrane
GO_0004930Molecular functionG protein-coupled receptor activity

IV. Literature review

[source]
Gene nameGPRC6A
Protein nameG-protein coupled receptor family C group 6 member A (hGPRC6A) (G-protein coupled receptor GPCR33) (hGPCR33)
Synonyms
DescriptionFUNCTION: Receptor activated by multiple ligands, including osteocalcin (BGLAP), basic amino acids, and various cations . Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids . The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+) (By similarity). Seems to act through a G(q)/G(11) and G(i)-coupled pathway (By similarity). Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (By similarity). Mediates the non-genomic effects of androgens in multiple tissue (By similarity). May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids . .

AccessionsENST00000530250.1 [Q5T6X5-2]
ENST00000368549.7 [Q5T6X5-3]
ENST00000310357.8 [Q5T6X5-1]
Q5T6X5