GNB2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	34 studies	34% ± 15%	Explore
fibroblast	31 studies	32% ± 14%	Explore
natural killer cell	30 studies	30% ± 13%	Explore
macrophage	28 studies	41% ± 17%	Explore
CD4-positive, alpha-beta T cell	26 studies	26% ± 9%	Explore
B cell	25 studies	27% ± 10%	Explore
pericyte	25 studies	36% ± 13%	Explore
classical monocyte	25 studies	47% ± 18%	Explore
CD8-positive, alpha-beta T cell	24 studies	29% ± 10%	Explore
conventional dendritic cell	24 studies	44% ± 21%	Explore
smooth muscle cell	23 studies	32% ± 11%	Explore
non-classical monocyte	23 studies	57% ± 21%	Explore
regulatory T cell	22 studies	31% ± 12%	Explore
T cell	20 studies	29% ± 11%	Explore
epithelial cell	18 studies	43% ± 21%	Explore
dendritic cell	17 studies	49% ± 20%	Explore
monocyte	17 studies	45% ± 15%	Explore
endothelial cell of lymphatic vessel	17 studies	43% ± 13%	Explore
ciliated cell	17 studies	46% ± 21%	Explore
mature NK T cell	16 studies	28% ± 12%	Explore
memory B cell	15 studies	27% ± 8%	Explore
plasmacytoid dendritic cell	15 studies	35% ± 12%	Explore
basal cell	15 studies	36% ± 19%	Explore
naive B cell	14 studies	23% ± 6%	Explore
gamma-delta T cell	14 studies	31% ± 11%	Explore
capillary endothelial cell	13 studies	35% ± 15%	Explore
connective tissue cell	13 studies	36% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	40% ± 14%	Explore
endothelial cell of artery	11 studies	41% ± 14%	Explore
myofibroblast cell	11 studies	35% ± 8%	Explore
vein endothelial cell	11 studies	34% ± 15%	Explore
myeloid cell	11 studies	41% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	31% ± 11%	Explore
mucosal invariant T cell	10 studies	29% ± 9%	Explore
secretory cell	10 studies	33% ± 15%	Explore
plasma cell	9 studies	29% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	34% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	27% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	22% ± 4%	Explore
abnormal cell	9 studies	36% ± 15%	Explore
endothelial cell of vascular tree	9 studies	32% ± 6%	Explore
type I pneumocyte	8 studies	31% ± 12%	Explore
neutrophil	8 studies	37% ± 18%	Explore
mast cell	8 studies	19% ± 4%	Explore
innate lymphoid cell	7 studies	25% ± 10%	Explore
plasmablast	7 studies	45% ± 23%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	34% ± 7%	Explore
leukocyte	7 studies	28% ± 11%	Explore
progenitor cell	7 studies	32% ± 15%	Explore
goblet cell	7 studies	35% ± 13%	Explore
alveolar macrophage	6 studies	45% ± 12%	Explore
club cell	6 studies	36% ± 5%	Explore
respiratory goblet cell	6 studies	38% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	33% ± 8%	Explore
neuron	6 studies	53% ± 30%	Explore
T follicular helper cell	6 studies	27% ± 7%	Explore
hematopoietic precursor cell	5 studies	34% ± 12%	Explore
ionocyte	5 studies	33% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	24% ± 7%	Explore
mononuclear phagocyte	5 studies	39% ± 18%	Explore
kidney loop of Henle epithelial cell	5 studies	22% ± 4%	Explore
enteroendocrine cell	5 studies	45% ± 20%	Explore
mesothelial cell	5 studies	50% ± 19%	Explore
transit amplifying cell	5 studies	24% ± 6%	Explore
brush cell	5 studies	27% ± 8%	Explore
type II pneumocyte	5 studies	36% ± 14%	Explore
intermediate monocyte	5 studies	56% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	37% ± 10%	Explore
erythrocyte	5 studies	49% ± 22%	Explore
exhausted T cell	4 studies	37% ± 12%	Explore
squamous epithelial cell	4 studies	49% ± 22%	Explore
enterocyte	4 studies	28% ± 3%	Explore
glutamatergic neuron	4 studies	27% ± 10%	Explore
precursor B cell	4 studies	36% ± 13%	Explore
adventitial cell	4 studies	29% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	37% ± 13%	Explore
oligodendrocyte precursor cell	4 studies	25% ± 7%	Explore
T-helper 17 cell	4 studies	25% ± 7%	Explore
CD4-positive helper T cell	3 studies	26% ± 9%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	30% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	29% ± 9%	Explore
deuterosomal cell	3 studies	31% ± 13%	Explore
duct epithelial cell	3 studies	30% ± 17%	Explore
pancreatic A cell	3 studies	57% ± 20%	Explore
type B pancreatic cell	3 studies	40% ± 22%	Explore
glomerular endothelial cell	3 studies	33% ± 4%	Explore
epithelial cell of proximal tubule	3 studies	25% ± 11%	Explore
neural crest cell	3 studies	30% ± 8%	Explore
extravillous trophoblast	3 studies	36% ± 16%	Explore
erythroblast	3 studies	42% ± 24%	Explore
lymphocyte	3 studies	40% ± 4%	Explore
megakaryocyte	3 studies	29% ± 6%	Explore
pro-B cell	3 studies	37% ± 14%	Explore
immature B cell	3 studies	37% ± 13%	Explore
retina horizontal cell	3 studies	32% ± 13%	Explore
microglial cell	3 studies	30% ± 12%	Explore
serous secreting cell	3 studies	29% ± 10%	Explore
intraepithelial lymphocyte	3 studies	23% ± 5%	Explore
Mueller cell	3 studies	23% ± 2%	Explore
germinal center B cell	3 studies	39% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	26% ± 6%	Explore
luminal cell of prostate epithelium	3 studies	37% ± 10%	Explore
granulocyte	3 studies	23% ± 4%	Explore
glial cell	3 studies	37% ± 20%	Explore
group 3 innate lymphoid cell	3 studies	39% ± 4%	Explore
keratinocyte	3 studies	29% ± 10%	Explore
T-helper 1 cell	3 studies	35% ± 11%	Explore
progenitor cell of mammary luminal epithelium	3 studies	21% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	35% ± 13%	Explore
lung	15 studies	40% ± 13%	Explore
intestine	8 studies	30% ± 13%	Explore
kidney	5 studies	27% ± 8%	Explore
lymph node	5 studies	36% ± 12%	Explore
brain	5 studies	26% ± 7%	Explore
uterus	4 studies	37% ± 16%	Explore
breast	4 studies	27% ± 8%	Explore
liver	4 studies	35% ± 24%	Explore
pancreas	3 studies	46% ± 22%	Explore
placenta	3 studies	33% ± 10%	Explore
bone marrow	3 studies	24% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	12964.33	1445 / 1445	100%	330.83	183 / 183
ovary	100%	10562.31	180 / 180	100%	329.15	430 / 430
pancreas	100%	6331.58	328 / 328	100%	318.74	178 / 178
uterus	100%	11804.63	170 / 170	100%	346.13	458 / 459
thymus	100%	9938.99	652 / 653	100%	292.05	604 / 605
brain	100%	8198.71	2630 / 2642	100%	349.14	705 / 705
prostate	100%	12218.98	245 / 245	99%	582.80	499 / 502
kidney	100%	10190.08	89 / 89	99%	237.61	895 / 901
stomach	100%	8411.04	359 / 359	99%	299.71	284 / 286
intestine	100%	9935.52	966 / 966	99%	335.16	523 / 527
skin	100%	15327.80	1809 / 1809	99%	317.54	468 / 472
breast	100%	12109.57	459 / 459	99%	325.80	1104 / 1118
lung	100%	13719.00	577 / 578	99%	283.00	1138 / 1155
liver	100%	6179.72	225 / 226	99%	170.66	401 / 406
adrenal gland	100%	12433.38	258 / 258	98%	338.70	226 / 230
bladder	100%	10227.90	21 / 21	98%	339.32	493 / 504
adipose	100%	12420.70	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	223.38	80 / 80
lymph node	0%	0	0 / 0	100%	322.16	29 / 29
peripheral blood	100%	25736.44	929 / 929	0%	0	0 / 0
spleen	100%	14885.92	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	325.83	45 / 45
ureter	0%	0	0 / 0	100%	198.96	1 / 1
blood vessel	100%	11728.65	1334 / 1335	0%	0	0 / 0
muscle	100%	6117.95	799 / 803	0%	0	0 / 0
heart	99%	6705.60	853 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_1901379	Biological process	regulation of potassium ion transmembrane transport
GO_0005615	Cellular component	extracellular space
GO_0005834	Cellular component	heterotrimeric G-protein complex
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0031982	Cellular component	vesicle
GO_0005886	Cellular component	plasma membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005925	Cellular component	focal adhesion
GO_0044877	Molecular function	protein-containing complex binding
GO_0051020	Molecular function	GTPase binding
GO_0030159	Molecular function	signaling receptor complex adaptor activity
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	GNB2
Protein name	Epididymis secretory sperm binding protein (GNB2 protein) (Guanine nucleotide binding protein (G protein), beta polypeptide 2, isoform CRA_a) (cDNA FLJ77321, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2 (GNB2), mRNA) Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) G protein subunit beta 2
Synonyms	hCG_20449
Description	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Accessions	ENST00000436220.5 P62879 ENST00000427895.5 [P62879-2] ENST00000303210.9 [P62879-1] E7EP32 ENST00000419828.5 [P62879-2] C9JZN1 Q6FHM2 ENST00000424361.5 ENST00000393924.1 [P62879-1] ENST00000431068.5 ENST00000412215.5 C9JIS1 ENST00000393926.5 [P62879-1] C9JXA5 ENST00000451587.5

GNB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review