AKT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0008283Biological processcell population proliferation
GO_0016242Biological processnegative regulation of macroautophagy
GO_0051247Biological processpositive regulation of protein metabolic process
GO_0070141Biological processresponse to UV-A
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0160049Biological processnegative regulation of cGAS/STING signaling pathway
GO_0034405Biological processresponse to fluid shear stress
GO_0046889Biological processpositive regulation of lipid biosynthetic process
GO_2000010Biological processpositive regulation of protein localization to cell surface
GO_0097011Biological processcellular response to granulocyte macrophage colony-stimulating factor stimulus
GO_1900087Biological processpositive regulation of G1/S transition of mitotic cell cycle
GO_0045861Biological processnegative regulation of proteolysis
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030334Biological processregulation of cell migration
GO_0072655Biological processestablishment of protein localization to mitochondrion
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0097194Biological processexecution phase of apoptosis
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_0006468Biological processprotein phosphorylation
GO_0032091Biological processnegative regulation of protein binding
GO_0006979Biological processresponse to oxidative stress
GO_0035924Biological processcellular response to vascular endothelial growth factor stimulus
GO_0006006Biological processglucose metabolic process
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_1990418Biological processresponse to insulin-like growth factor stimulus
GO_0031999Biological processnegative regulation of fatty acid beta-oxidation
GO_0031641Biological processregulation of myelination
GO_0009408Biological processresponse to heat
GO_0010748Biological processnegative regulation of long-chain fatty acid import across plasma membrane
GO_0010629Biological processnegative regulation of gene expression
GO_0001649Biological processosteoblast differentiation
GO_0007165Biological processsignal transduction
GO_0010761Biological processfibroblast migration
GO_0010763Biological processpositive regulation of fibroblast migration
GO_0010628Biological processpositive regulation of gene expression
GO_0031295Biological processT cell costimulation
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0071276Biological processcellular response to cadmium ion
GO_0060416Biological processresponse to growth hormone
GO_0003376Biological processsphingosine-1-phosphate receptor signaling pathway
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0042981Biological processregulation of apoptotic process
GO_0010765Biological processpositive regulation of sodium ion transport
GO_0060716Biological processlabyrinthine layer blood vessel development
GO_0006809Biological processnitric oxide biosynthetic process
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0045429Biological processpositive regulation of nitric oxide biosynthetic process
GO_0006606Biological processprotein import into nucleus
GO_0060644Biological processmammary gland epithelial cell differentiation
GO_0010907Biological processpositive regulation of glucose metabolic process
GO_0010975Biological processregulation of neuron projection development
GO_0032079Biological processpositive regulation of endodeoxyribonuclease activity
GO_0010467Biological processgene expression
GO_0046777Biological processprotein autophosphorylation
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0150033Biological processnegative regulation of protein localization to lysosome
GO_0070848Biological processresponse to growth factor
GO_0043154Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0071380Biological processcellular response to prostaglandin E stimulus
GO_0001893Biological processmaternal placenta development
GO_0016567Biological processprotein ubiquitination
GO_2000074Biological processregulation of type B pancreatic cell development
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0005979Biological processregulation of glycogen biosynthetic process
GO_0032869Biological processcellular response to insulin stimulus
GO_0005978Biological processglycogen biosynthetic process
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0043536Biological processpositive regulation of blood vessel endothelial cell migration
GO_0010951Biological processnegative regulation of endopeptidase activity
GO_0060079Biological processexcitatory postsynaptic potential
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0090201Biological processnegative regulation of release of cytochrome c from mitochondria
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0051146Biological processstriated muscle cell differentiation
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0008286Biological processinsulin receptor signaling pathway
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_1990090Biological processcellular response to nerve growth factor stimulus
GO_1903721Biological processpositive regulation of I-kappaB phosphorylation
GO_0016310Biological processphosphorylation
GO_0019049Biological processvirus-mediated perturbation of host defense response
GO_0048266Biological processbehavioral response to pain
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0046622Biological processpositive regulation of organ growth
GO_0140052Biological processcellular response to oxidised low-density lipoprotein particle stimulus
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0071901Biological processnegative regulation of protein serine/threonine kinase activity
GO_1901653Biological processcellular response to peptide
GO_0031663Biological processlipopolysaccharide-mediated signaling pathway
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_1902018Biological processnegative regulation of cilium assembly
GO_0046326Biological processpositive regulation of glucose import
GO_0034614Biological processcellular response to reactive oxygen species
GO_0042593Biological processglucose homeostasis
GO_0043488Biological processregulation of mRNA stability
GO_0030307Biological processpositive regulation of cell growth
GO_2000402Biological processnegative regulation of lymphocyte migration
GO_1905552Biological processpositive regulation of protein localization to endoplasmic reticulum
GO_0002042Biological processcell migration involved in sprouting angiogenesis
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0031929Biological processTOR signaling
GO_0043276Biological processanoikis
GO_0045737Biological processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
GO_1902176Biological processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO_0022605Biological processmammalian oogenesis stage
GO_0036294Biological processcellular response to decreased oxygen levels
GO_0045725Biological processpositive regulation of glycogen biosynthetic process
GO_0006417Biological processregulation of translation
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0110002Biological processregulation of tRNA methylation
GO_0008637Biological processapoptotic mitochondrial changes
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_0035556Biological processintracellular signal transduction
GO_0032287Biological processperipheral nervous system myelin maintenance
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0030335Biological processpositive regulation of cell migration
GO_0072656Biological processmaintenance of protein location in mitochondrion
GO_0030154Biological processcell differentiation
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0006924Biological processactivation-induced cell death of T cells
GO_0010507Biological processnegative regulation of autophagy
GO_0035655Biological processinterleukin-18-mediated signaling pathway
GO_2001240Biological processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0051000Biological processpositive regulation of nitric-oxide synthase activity
GO_1903038Biological processnegative regulation of leukocyte cell-cell adhesion
GO_0032094Biological processresponse to food
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0099175Biological processregulation of postsynapse organization
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0098978Cellular componentglutamatergic synapse
GO_0098794Cellular componentpostsynapse
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0030027Cellular componentlamellipodium
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0032991Cellular componentprotein-containing complex
GO_0005737Cellular componentcytoplasm
GO_0036064Cellular componentciliary basal body
GO_0005911Cellular componentcell-cell junction
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0031982Cellular componentvesicle
GO_0005819Cellular componentspindle
GO_0030291Molecular functionprotein serine/threonine kinase inhibitor activity
GO_0042802Molecular functionidentical protein binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0005547Molecular functionphosphatidylinositol-3,4,5-trisphosphate binding
GO_0004712Molecular functionprotein serine/threonine/tyrosine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0071889Molecular function14-3-3 protein binding
GO_0005516Molecular functioncalmodulin binding
GO_0043325Molecular functionphosphatidylinositol-3,4-bisphosphate binding
GO_0019899Molecular functionenzyme binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005515Molecular functionprotein binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0019901Molecular functionprotein kinase binding
GO_0030235Molecular functionnitric-oxide synthase regulator activity
GO_0099104Molecular functionpotassium channel activator activity
GO_0016301Molecular functionkinase activity

IV. Literature review

[source]
Gene nameAKT1
Protein nameSerine-threonine protein kinase
V-akt murine thymoma viral oncogene-like protein 1 isoform 2
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
AKT1m transcript variant 3
non-specific serine/threonine protein kinase (EC 2.7.11.1)
AKT serine/threonine kinase 1
AKT1m transcript variant 1 (AKT1m transcript variant 2) (AKT1m transcript variant 4)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha)
SynonymsPKB
hCG_96740
RAC
DescriptionFUNCTION: AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis . This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates . Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported . AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (By similarity). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport . AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity (By similarity). Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase) . Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis . AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating the mTORC1 signaling pathway, and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1 . Also regulates the mTORC1 signaling pathway by catalyzing phosphorylation of CASTOR1 and DEPDC5 . AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization . In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319' . FOXO3 and FOXO4 are phosphorylated on equivalent sites . AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein) . The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 . AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (By similarity). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (By similarity). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (By similarity). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth (By similarity). AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) . AKT mediates the antiapoptotic effects of IGF-I (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly . May be involved in the regulation of the placental development (By similarity). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3 . Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation . Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation . Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity . Phosphorylation of BAD stimulates its pro-apoptotic activity . Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53 . Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility . Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation . Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization . These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation . Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation . Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor . Also acts as an activator of TMEM175 potassium channel activity in response to growth factors: forms the lysoK(GF) complex together with TMEM175 and acts by promoting TMEM175 channel activation, independently of its protein kinase activity . Acts as an inhibitor of tRNA methylation by mediating phosphorylation of the N-terminus of METTL1, thereby inhibiting METTL1 methyltransferase activity . In response to LPAR1 receptor pathway activation, phosphorylates Rabin8/RAB3IP which alters its activity and phosphorylates WDR44 which induces WDR44 binding to Rab11, thereby switching Rab11 vesicular function from preciliary trafficking to endocytic recycling . .

AccessionsENST00000555458.6
B0LPE5
ENST00000554581.5 [P31749-1]
ENST00000555528.5 [P31749-1]
G3V3X1
ENST00000407796.7 [P31749-1]
X2CVF3
ENST00000349310.7 [P31749-1]
A0A087WY56
ENST00000402615.6 [P31749-1]
A0A142IKA9
ENST00000554585.6
ENST00000553797.2
ENST00000683722.1 [P31749-1]
P31749
ENST00000649815.2 [P31749-1]
X2CV47
A0A0S2Z3D6
ENST00000554848.5 [P31749-1]
ENST00000554192.6
G3V2I6
A0A804HJM6