GNG2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	41 studies	46% ± 16%	Explore
CD8-positive, alpha-beta T cell	36 studies	32% ± 12%	Explore
T cell	32 studies	30% ± 8%	Explore
CD4-positive, alpha-beta T cell	27 studies	30% ± 8%	Explore
regulatory T cell	24 studies	34% ± 8%	Explore
mature NK T cell	20 studies	38% ± 13%	Explore
non-classical monocyte	19 studies	35% ± 14%	Explore
gamma-delta T cell	17 studies	37% ± 15%	Explore
macrophage	17 studies	30% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	61% ± 12%	Explore
mucosal invariant T cell	14 studies	35% ± 12%	Explore
oligodendrocyte precursor cell	14 studies	30% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	33% ± 11%	Explore
B cell	12 studies	19% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	38% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	40% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	28% ± 9%	Explore
glutamatergic neuron	11 studies	35% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	30% ± 9%	Explore
classical monocyte	10 studies	24% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	21% ± 4%	Explore
monocyte	10 studies	24% ± 7%	Explore
naive B cell	8 studies	25% ± 8%	Explore
neuron	8 studies	37% ± 18%	Explore
memory B cell	8 studies	21% ± 6%	Explore
GABAergic neuron	8 studies	41% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	42% ± 11%	Explore
leukocyte	7 studies	31% ± 14%	Explore
interneuron	7 studies	44% ± 13%	Explore
myeloid cell	7 studies	26% ± 8%	Explore
dendritic cell	7 studies	26% ± 8%	Explore
adipocyte	7 studies	28% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	40% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	30% ± 5%	Explore
microglial cell	6 studies	26% ± 7%	Explore
mast cell	6 studies	27% ± 8%	Explore
exhausted T cell	5 studies	36% ± 6%	Explore
endothelial cell	5 studies	36% ± 17%	Explore
glial cell	5 studies	36% ± 13%	Explore
lymphocyte	5 studies	39% ± 15%	Explore
fibroblast	5 studies	21% ± 8%	Explore
T follicular helper cell	5 studies	29% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	33% ± 6%	Explore
conventional dendritic cell	4 studies	27% ± 9%	Explore
enteroendocrine cell	4 studies	26% ± 10%	Explore
T-helper 17 cell	4 studies	30% ± 10%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	33% ± 8%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	22% ± 5%	Explore
neutrophil	3 studies	32% ± 10%	Explore
plasmablast	3 studies	22% ± 4%	Explore
pancreatic A cell	3 studies	39% ± 16%	Explore
type B pancreatic cell	3 studies	35% ± 13%	Explore
GABAergic interneuron	3 studies	33% ± 10%	Explore
astrocyte	3 studies	32% ± 9%	Explore
myofibroblast cell	3 studies	26% ± 3%	Explore
Schwann cell	3 studies	43% ± 18%	Explore
pro-B cell	3 studies	24% ± 3%	Explore
mononuclear phagocyte	3 studies	22% ± 5%	Explore
GABAergic amacrine cell	3 studies	25% ± 3%	Explore
CD4-positive helper T cell	3 studies	34% ± 19%	Explore
innate lymphoid cell	3 studies	34% ± 11%	Explore
pericyte	3 studies	27% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	23% ± 6%	Explore
T-helper 1 cell	3 studies	41% ± 5%	Explore
double negative thymocyte	3 studies	43% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	15 studies	27% ± 6%	Explore
brain	9 studies	34% ± 13%	Explore
lung	3 studies	20% ± 2%	Explore
pancreas	3 studies	29% ± 10%	Explore
bone marrow	3 studies	28% ± 7%	Explore
adipose	3 studies	21% ± 4%	Explore
lymph node	3 studies	20% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	83%	3469.83	2184 / 2642	100%	53.80	704 / 705
breast	98%	2620.34	450 / 459	80%	8.33	897 / 1118
lung	93%	1284.89	539 / 578	69%	6.26	792 / 1155
intestine	96%	2500.76	926 / 966	43%	4.13	229 / 527
skin	46%	514.56	828 / 1809	93%	48.73	441 / 472
prostate	87%	1221.91	213 / 245	42%	2.86	213 / 502
adrenal gland	50%	488.58	129 / 258	76%	33.22	174 / 230
esophagus	62%	864.85	896 / 1445	55%	4.58	101 / 183
thymus	52%	461.92	342 / 653	59%	6.78	355 / 605
stomach	47%	672.14	170 / 359	63%	6.36	179 / 286
kidney	36%	327.71	32 / 89	67%	9.05	604 / 901
spleen	100%	4142.22	241 / 241	0%	0	0 / 0
adipose	100%	3170.64	1201 / 1204	0%	0	0 / 0
peripheral blood	100%	4974.18	925 / 929	0%	0	0 / 0
uterus	55%	530.03	94 / 170	44%	4.89	200 / 459
ovary	70%	980.50	126 / 180	27%	1.90	117 / 430
lymph node	0%	0	0 / 0	97%	36.35	28 / 29
pancreas	4%	34.37	14 / 328	80%	12.34	143 / 178
bladder	38%	466.38	8 / 21	37%	3.27	187 / 504
tonsil	0%	0	0 / 0	69%	7.35	31 / 45
heart	43%	503.41	373 / 861	0%	0	0 / 0
blood vessel	28%	321.69	369 / 1335	0%	0	0 / 0
liver	8%	56.63	17 / 226	17%	1.21	69 / 406
eye	0%	0	0 / 0	16%	1.15	13 / 80
muscle	1%	10.56	12 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007191	Biological process	adenylate cyclase-activating dopamine receptor signaling pathway
GO_0071380	Biological process	cellular response to prostaglandin E stimulus
GO_0071870	Biological process	cellular response to catecholamine stimulus
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0048144	Biological process	fibroblast proliferation
GO_0005834	Cellular component	heterotrimeric G-protein complex
GO_0070062	Cellular component	extracellular exosome
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0031681	Molecular function	G-protein beta-subunit binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	GNG2
Protein name	Guanine nucleotide-binding protein subunit gamma G protein subunit gamma 2 (Guanine nucleotide binding protein (G protein), gamma 2, isoform CRA_b) G protein subunit gamma 2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)
Synonyms	hCG_2013367
Description	FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). . FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. . FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. .
Accessions	G3V415 ENST00000554736.5 ENST00000335281.8 G3V2N0 ENST00000556766.6 ENST00000557376.5 ENST00000553432.5 P59768 G3V2W5 ENST00000555472.5 ENST00000556752.2 ENST00000554875.1 G3V3J9 ENST00000615906.4 ENST00000553560.5 ENST00000556522.5 G3V2C9

GNG2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review