GPHB5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPHB5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPHB5 at tissue level.

III. Associated gene sets

GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0002155Biological processregulation of thyroid hormone receptor signaling pathway
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005737Cellular componentcytoplasm
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005179Molecular functionhormone activity
GO_0031531Molecular functionthyrotropin-releasing hormone receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPHB5
Protein nameGlycoprotein hormone beta 5 (Glycoprotein-beta 5)
GPHB5 protein
Glycoprotein hormone beta-5 (Thyrostimulin subunit beta)
SynonymshCG_1647688
GPB5
ZLUT1
DescriptionFUNCTION: Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. .

AccessionsQ86YW7
A4IF52
ENST00000621500.2
A0A0F7RPU1
ENST00000314140.2