PIK3R6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PIK3R6 at tissue level.

III. Associated gene sets

GO_0043406Biological processpositive regulation of MAP kinase activity
GO_0006955Biological processimmune response
GO_0001525Biological processangiogenesis
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0045766Biological processpositive regulation of angiogenesis
GO_0042269Biological processregulation of natural killer cell mediated cytotoxicity
GO_0005942Cellular componentphosphatidylinositol 3-kinase complex
GO_0005943Cellular componentphosphatidylinositol 3-kinase complex, class IA
GO_0005944Cellular componentphosphatidylinositol 3-kinase complex, class IB
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0046934Molecular function1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO_0005515Molecular functionprotein binding
GO_0046935Molecular function1-phosphatidylinositol-3-kinase regulator activity

IV. Literature review

[source]
Gene namePIK3R6
Protein namePhosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP)
Phosphoinositide-3-kinase regulatory subunit 6
PIK3R6 protein
SynonymsC17orf38
DescriptionFUNCTION: Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. .

AccessionsENST00000613555.4
ENST00000611951.4
ENST00000619866.5
A0A087X1F3
Q5UE93
A4FVB8