Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| enterocyte | 8 studies | 57% ± 26% | |
| hepatocyte | 6 studies | 79% ± 25% | |
| endothelial cell | 4 studies | 60% ± 30% | |
| endothelial cell of sinusoid | 4 studies | 41% ± 18% | |
| enteroendocrine cell | 4 studies | 39% ± 28% | |
| epithelial cell | 4 studies | 74% ± 19% | |
| cholangiocyte | 3 studies | 63% ± 34% | |
| hepatic stellate cell | 3 studies | 69% ± 29% | |
| goblet cell | 3 studies | 34% ± 21% | |
| macrophage | 3 studies | 57% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 288131.23 | 226 / 226 | 96% | 10670.45 | 391 / 406 |
| ovary | 98% | 702.74 | 177 / 180 | 97% | 261.37 | 415 / 430 |
| stomach | 82% | 289.19 | 293 / 359 | 24% | 52.63 | 69 / 286 |
| thymus | 85% | 111.92 | 556 / 653 | 19% | 7.70 | 115 / 605 |
| heart | 98% | 772.93 | 844 / 861 | 0% | 0 | 0 / 0 |
| spleen | 80% | 332.88 | 193 / 241 | 0% | 0 | 0 / 0 |
| lung | 73% | 73.22 | 422 / 578 | 6% | 26.08 | 67 / 1155 |
| uterus | 62% | 70.76 | 106 / 170 | 8% | 13.14 | 36 / 459 |
| intestine | 37% | 3337.34 | 353 / 966 | 13% | 27.91 | 70 / 527 |
| pancreas | 28% | 23.08 | 93 / 328 | 21% | 9.58 | 38 / 178 |
| adrenal gland | 32% | 24.56 | 83 / 258 | 17% | 30.04 | 39 / 230 |
| kidney | 38% | 26.53 | 34 / 89 | 4% | 2.46 | 34 / 901 |
| prostate | 34% | 28.27 | 83 / 245 | 3% | 0.51 | 17 / 502 |
| esophagus | 24% | 24.83 | 348 / 1445 | 12% | 33.58 | 22 / 183 |
| brain | 34% | 21.38 | 893 / 2642 | 1% | 0.11 | 6 / 705 |
| peripheral blood | 25% | 82.61 | 233 / 929 | 0% | 0 | 0 / 0 |
| breast | 18% | 49.42 | 84 / 459 | 5% | 2.07 | 52 / 1118 |
| adipose | 22% | 43.63 | 267 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 19% | 28.99 | 250 / 1335 | 0% | 0 | 0 / 0 |
| skin | 10% | 14.40 | 179 / 1809 | 6% | 2.56 | 27 / 472 |
| muscle | 8% | 6.06 | 66 / 803 | 0% | 0 | 0 / 0 |
| bladder | 0% | 0 | 0 / 21 | 7% | 1.81 | 36 / 504 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.60 | 1 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.18 | 1 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0055091 | Biological process | phospholipid homeostasis |
| GO_0032489 | Biological process | regulation of Cdc42 protein signal transduction |
| GO_0034115 | Biological process | negative regulation of heterotypic cell-cell adhesion |
| GO_0070508 | Biological process | cholesterol import |
| GO_0050728 | Biological process | negative regulation of inflammatory response |
| GO_0050821 | Biological process | protein stabilization |
| GO_1900026 | Biological process | positive regulation of substrate adhesion-dependent cell spreading |
| GO_0033344 | Biological process | cholesterol efflux |
| GO_0070328 | Biological process | triglyceride homeostasis |
| GO_0030300 | Biological process | regulation of intestinal cholesterol absorption |
| GO_0006656 | Biological process | phosphatidylcholine biosynthetic process |
| GO_0008211 | Biological process | glucocorticoid metabolic process |
| GO_0033700 | Biological process | phospholipid efflux |
| GO_0032691 | Biological process | negative regulation of interleukin-1 beta production |
| GO_0055090 | Biological process | acylglycerol homeostasis |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0007229 | Biological process | integrin-mediated signaling pathway |
| GO_0070371 | Biological process | ERK1 and ERK2 cascade |
| GO_0019915 | Biological process | lipid storage |
| GO_0018206 | Biological process | peptidyl-methionine modification |
| GO_0030325 | Biological process | adrenal gland development |
| GO_0060354 | Biological process | negative regulation of cell adhesion molecule production |
| GO_0051180 | Biological process | vitamin transport |
| GO_0006695 | Biological process | cholesterol biosynthetic process |
| GO_0010804 | Biological process | negative regulation of tumor necrosis factor-mediated signaling pathway |
| GO_0002719 | Biological process | negative regulation of cytokine production involved in immune response |
| GO_0051496 | Biological process | positive regulation of stress fiber assembly |
| GO_0090205 | Biological process | positive regulation of cholesterol metabolic process |
| GO_0034375 | Biological process | high-density lipoprotein particle remodeling |
| GO_0050919 | Biological process | negative chemotaxis |
| GO_0043534 | Biological process | blood vessel endothelial cell migration |
| GO_1902995 | Biological process | positive regulation of phospholipid efflux |
| GO_0051345 | Biological process | positive regulation of hydrolase activity |
| GO_0030301 | Biological process | cholesterol transport |
| GO_0010903 | Biological process | negative regulation of very-low-density lipoprotein particle remodeling |
| GO_0050766 | Biological process | positive regulation of phagocytosis |
| GO_0042158 | Biological process | lipoprotein biosynthetic process |
| GO_0018158 | Biological process | protein oxidation |
| GO_0008203 | Biological process | cholesterol metabolic process |
| GO_0043691 | Biological process | reverse cholesterol transport |
| GO_0001932 | Biological process | regulation of protein phosphorylation |
| GO_1905920 | Biological process | positive regulation of CoA-transferase activity |
| GO_0060761 | Biological process | negative regulation of response to cytokine stimulus |
| GO_0034384 | Biological process | high-density lipoprotein particle clearance |
| GO_0034380 | Biological process | high-density lipoprotein particle assembly |
| GO_0001935 | Biological process | endothelial cell proliferation |
| GO_0010875 | Biological process | positive regulation of cholesterol efflux |
| GO_0035025 | Biological process | positive regulation of Rho protein signal transduction |
| GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
| GO_0042632 | Biological process | cholesterol homeostasis |
| GO_0030139 | Cellular component | endocytic vesicle |
| GO_1903561 | Cellular component | extracellular vesicle |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0034361 | Cellular component | very-low-density lipoprotein particle |
| GO_0042627 | Cellular component | chylomicron |
| GO_0005576 | Cellular component | extracellular region |
| GO_0034362 | Cellular component | low-density lipoprotein particle |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0034366 | Cellular component | spherical high-density lipoprotein particle |
| GO_0031410 | Cellular component | cytoplasmic vesicle |
| GO_0005769 | Cellular component | early endosome |
| GO_0034774 | Cellular component | secretory granule lumen |
| GO_0072562 | Cellular component | blood microparticle |
| GO_0071682 | Cellular component | endocytic vesicle lumen |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0034364 | Cellular component | high-density lipoprotein particle |
| GO_0005829 | Cellular component | cytosol |
| GO_0034191 | Molecular function | apolipoprotein A-I receptor binding |
| GO_0015485 | Molecular function | cholesterol binding |
| GO_0120020 | Molecular function | cholesterol transfer activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0070653 | Molecular function | high-density lipoprotein particle receptor binding |
| GO_0001540 | Molecular function | amyloid-beta binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0045499 | Molecular function | chemorepellent activity |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0034190 | Molecular function | apolipoprotein receptor binding |
| GO_0031072 | Molecular function | heat shock protein binding |
| GO_0008035 | Molecular function | high-density lipoprotein particle binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0005543 | Molecular function | phospholipid binding |
| GO_0060228 | Molecular function | phosphatidylcholine-sterol O-acyltransferase activator activity |
| Gene name | APOA1 |
| Protein name | APOA1 protein (Apolipoprotein A1) Apolipoprotein A-I Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))] |
| Synonyms | |
| Description | FUNCTION: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. . FUNCTION: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. . |
| Accessions | P02647 F8W696 ENST00000236850.5 ENST00000375329.6 ENST00000359492.6 Q6LEJ8 ENST00000375320.5 ENST00000375323.5 |
