I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal ganglion cell | 4 studies | 32% ± 11% | |
| GABAergic neuron | 4 studies | 36% ± 22% | |
| interneuron | 4 studies | 37% ± 27% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retinal ganglion cell | 4 studies | 32% ± 11% | |
| GABAergic neuron | 4 studies | 36% ± 22% | |
| interneuron | 4 studies | 37% ± 27% |
Insufficient scRNA-seq data for expression of ECE2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 3806.98 | 2631 / 2642 | 29% | 0.55 | 205 / 705 |
| adrenal gland | 61% | 489.97 | 158 / 258 | 42% | 1.18 | 96 / 230 |
| pancreas | 100% | 2645.74 | 328 / 328 | 1% | 0.01 | 1 / 178 |
| liver | 88% | 500.69 | 199 / 226 | 0% | 0 | 0 / 406 |
| intestine | 66% | 277.24 | 638 / 966 | 0% | 0.01 | 2 / 527 |
| stomach | 62% | 241.47 | 224 / 359 | 0% | 0 | 0 / 286 |
| skin | 61% | 255.76 | 1100 / 1809 | 0% | 0.00 | 1 / 472 |
| thymus | 58% | 260.19 | 381 / 653 | 0% | 0 | 0 / 605 |
| muscle | 50% | 255.40 | 402 / 803 | 0% | 0 | 0 / 0 |
| prostate | 48% | 218.16 | 117 / 245 | 0% | 0 | 0 / 502 |
| esophagus | 44% | 187.28 | 642 / 1445 | 0% | 0 | 0 / 183 |
| heart | 36% | 179.76 | 314 / 861 | 0% | 0 | 0 / 0 |
| breast | 28% | 99.08 | 127 / 459 | 0% | 0.00 | 2 / 1118 |
| lung | 26% | 113.21 | 152 / 578 | 1% | 0.01 | 6 / 1155 |
| peripheral blood | 24% | 126.89 | 225 / 929 | 0% | 0 | 0 / 0 |
| kidney | 20% | 77.26 | 18 / 89 | 0% | 0 | 0 / 901 |
| adipose | 19% | 76.30 | 229 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 18% | 64.05 | 44 / 241 | 0% | 0 | 0 / 0 |
| bladder | 14% | 62.29 | 3 / 21 | 0% | 0.00 | 1 / 504 |
| blood vessel | 7% | 25.47 | 95 / 1335 | 0% | 0 | 0 / 0 |
| uterus | 3% | 10.70 | 5 / 170 | 1% | 0.01 | 3 / 459 |
| ovary | 2% | 6.52 | 4 / 180 | 0% | 0 | 0 / 430 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0016486 | Biological process | peptide hormone processing |
| GO_0016485 | Biological process | protein processing |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0032259 | Biological process | methylation |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0030658 | Cellular component | transport vesicle membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030659 | Cellular component | cytoplasmic vesicle membrane |
| GO_0004222 | Molecular function | metalloendopeptidase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0008168 | Molecular function | methyltransferase activity |
| Gene name | ECE2 |
| Protein name | Endothelin converting enzyme 2 Endothelin-converting enzyme 2 (ECE-2) (EC 3.4.24.71) endothelin-converting enzyme 1 (EC 3.4.24.71) |
| Synonyms | UNQ403/PRO740 KIAA0604 |
| Description | FUNCTION: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May play a role in amyloid-beta processing (By similarity). . |
| Accessions | P0DPD6 ENST00000430587.1 H0Y5G8 ENST00000357474.9 [P0DPD6-4] F8WCL9 ENST00000359140.8 [P0DPD6-3] ENST00000422932.5 ENST00000404464.8 [P0DPD6-2] |
