GPRC5A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0007175Biological processnegative regulation of epidermal growth factor-activated receptor activity
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005730Cellular componentnucleolus
GO_0070062Cellular componentextracellular exosome
GO_0043235Cellular componentreceptor complex
GO_0031982Cellular componentvesicle
GO_0005886Cellular componentplasma membrane
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0045296Molecular functioncadherin binding
GO_0030295Molecular functionprotein kinase activator activity
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPRC5A
Protein nameRetinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1)
G protein-coupled receptor class C group 5 member A
SynonymsRAI3
GPCR5A
RAIG1
DescriptionFUNCTION: Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor . .

AccessionsA0A3B3ITN8
ENST00000540125.1
Q8NFJ5
ENST00000534831.1
ENST00000014914.6
H0YFN2
F5GWG3
ENST00000648791.1