DGKQ report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DGKQ at tissue level.

III. Associated gene sets

GO_0090181Biological processregulation of cholesterol metabolic process
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_1900242Biological processregulation of synaptic vesicle endocytosis
GO_0010629Biological processnegative regulation of gene expression
GO_1903432Biological processregulation of TORC1 signaling
GO_0033198Biological processresponse to ATP
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_2000182Biological processregulation of progesterone biosynthetic process
GO_0010628Biological processpositive regulation of gene expression
GO_0046339Biological processdiacylglycerol metabolic process
GO_0019933Biological processcAMP-mediated signaling
GO_0046486Biological processglycerolipid metabolic process
GO_0070493Biological processthrombin-activated receptor signaling pathway
GO_2000064Biological processregulation of cortisol biosynthetic process
GO_0046834Biological processlipid phosphorylation
GO_0006111Biological processregulation of gluconeogenesis
GO_0030168Biological processplatelet activation
GO_0010801Biological processnegative regulation of peptidyl-threonine phosphorylation
GO_0051591Biological processresponse to cAMP
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0006654Biological processphosphatidic acid biosynthetic process
GO_0070528Biological processprotein kinase C signaling
GO_0007205Biological processprotein kinase C-activating G protein-coupled receptor signaling pathway
GO_0098978Cellular componentglutamatergic synapse
GO_0005730Cellular componentnucleolus
GO_0098793Cellular componentpresynapse
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0012506Cellular componentvesicle membrane
GO_0016607Cellular componentnuclear speck
GO_0098794Cellular componentpostsynapse
GO_0016363Cellular componentnuclear matrix
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005768Cellular componentendosome
GO_0005634Cellular componentnucleus
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0019900Molecular functionkinase binding
GO_0043274Molecular functionphospholipase binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0047649Molecular functionalkylglycerol kinase activity
GO_0004143Molecular functionATP-dependent diacylglycerol kinase activity
GO_0030297Molecular functiontransmembrane receptor protein tyrosine kinase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDGKQ
Protein nameDiacylglycerol kinase (DAG kinase) (EC 2.7.1.107)
Diacylglycerol kinase theta (DAG kinase theta) (DGKtheta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase theta) (DGK-theta)
Diacylglycerol kinase theta
SynonymsDAGK4
DescriptionFUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids . Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes . Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription . Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis . .

AccessionsD6RJB4
H0Y8Q7
ENST00000509465.5
ENST00000510286.1
H0YA20
ENST00000515182.1
ENST00000273814.8
P52824