SCTR report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SCTR at tissue level.

III. Associated gene sets

GO_0002024Biological processdiet induced thermogenesis
GO_0031667Biological processresponse to nutrient levels
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0048167Biological processregulation of synaptic plasticity
GO_0007188Biological processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0009992Biological processintracellular water homeostasis
GO_0032098Biological processregulation of appetite
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005881Cellular componentcytoplasmic microtubule
GO_0005886Cellular componentplasma membrane
GO_0008528Molecular functionG protein-coupled peptide receptor activity
GO_0017046Molecular functionpeptide hormone binding
GO_0015055Molecular functionsecretin receptor activity

IV. Literature review

[source]
Gene nameSCTR
Protein nameSecretin receptor (SCT-R)
Secretin receptor
Synonyms
DescriptionFUNCTION: Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis . The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity). .

AccessionsQ8IV17
ENST00000630739.2
A0A0D9SFY2
ENST00000019103.8
P47872
A0A0D9SFV7
ENST00000627145.1