INPP5K report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of INPP5K at tissue level.

III. Associated gene sets

GO_0045869Biological processnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0005979Biological processregulation of glycogen biosynthetic process
GO_0072659Biological processprotein localization to plasma membrane
GO_0032869Biological processcellular response to insulin stimulus
GO_0001701Biological processin utero embryonic development
GO_0051926Biological processnegative regulation of calcium ion transport
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0043922Biological processnegative regulation by host of viral transcription
GO_0032870Biological processcellular response to hormone stimulus
GO_0046856Biological processphosphatidylinositol dephosphorylation
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0097178Biological processruffle assembly
GO_0035305Biological processnegative regulation of dephosphorylation
GO_2000466Biological processnegative regulation of glycogen (starch) synthase activity
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0010801Biological processnegative regulation of peptidyl-threonine phosphorylation
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0030036Biological processactin cytoskeleton organization
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0071320Biological processcellular response to cAMP
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0090315Biological processnegative regulation of protein targeting to membrane
GO_0016311Biological processdephosphorylation
GO_0010829Biological processnegative regulation of glucose transmembrane transport
GO_0043407Biological processnegative regulation of MAP kinase activity
GO_0033137Biological processnegative regulation of peptidyl-serine phosphorylation
GO_0045719Biological processnegative regulation of glycogen biosynthetic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0035810Biological processpositive regulation of urine volume
GO_2001153Biological processpositive regulation of renal water transport
GO_0042593Biological processglucose homeostasis
GO_0051497Biological processnegative regulation of stress fiber assembly
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0001726Cellular componentruffle
GO_0032587Cellular componentruffle membrane
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0043005Cellular componentneuron projection
GO_0005802Cellular componenttrans-Golgi network
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0052658Molecular functioninositol-1,4,5-trisphosphate 5-phosphatase activity
GO_0016312Molecular functioninositol bisphosphate phosphatase activity
GO_0034485Molecular functionphosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO_0046030Molecular functioninositol trisphosphate phosphatase activity
GO_0004439Molecular functionphosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO_0034595Molecular functionphosphatidylinositol phosphate 5-phosphatase activity
GO_0034594Molecular functionphosphatidylinositol trisphosphate phosphatase activity
GO_0005000Molecular functionvasopressin receptor activity
GO_0052659Molecular functioninositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO_0004445Molecular functioninositol-polyphosphate 5-phosphatase activity
GO_0042577Molecular functionlipid phosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameINPP5K
Protein namephosphoinositide 5-phosphatase (EC 3.1.3.36)
Inositol polyphosphate-5-phosphatase K
Inositol polyphosphate 5-phosphatase K (EC 3.1.3.56) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Skeletal muscle and kidney-enriched inositol phosphatase)
inositol-polyphosphate 5-phosphatase (EC 3.1.3.56)
SynonymsPPS
SKIP
DescriptionFUNCTION: Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate . Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate . Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity). .

AccessionsK7ENF7
ENST00000571274.5
I3L4A5
Q9BT40
ENST00000320345.10 [Q9BT40-2]
ENST00000477910.5
ENST00000421807.7 [Q9BT40-1]
ENST00000576646.7
K7EMS8
K7EPG6
ENST00000573790.5
ENST00000574955.1
ENST00000445774.2
I3L1R1
ENST00000406424.8 [Q9BT40-2]
I3L0Y0
ENST00000350761.9
C9JZB0
ENST00000449479.5
ENST00000574561.1
ENST00000575172.5
C9JQW8
I3L2L1
I3NI31
ENST00000498390.5
J3KN07