Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 13 studies | 39% ± 16% | |
| vein endothelial cell | 6 studies | 52% ± 28% | |
| capillary endothelial cell | 4 studies | 50% ± 26% | |
| glomerular endothelial cell | 3 studies | 24% ± 7% |
Insufficient scRNA-seq data for expression of APLNR at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 96% | 1872.54 | 624 / 653 | 90% | 37.30 | 546 / 605 |
| brain | 84% | 3512.60 | 2212 / 2642 | 97% | 180.84 | 684 / 705 |
| breast | 71% | 1948.13 | 324 / 459 | 93% | 37.13 | 1041 / 1118 |
| intestine | 60% | 675.32 | 584 / 966 | 77% | 21.51 | 404 / 527 |
| liver | 69% | 836.19 | 157 / 226 | 62% | 16.05 | 251 / 406 |
| adrenal gland | 67% | 600.60 | 172 / 258 | 62% | 21.89 | 142 / 230 |
| kidney | 63% | 688.54 | 56 / 89 | 63% | 44.91 | 565 / 901 |
| stomach | 31% | 259.91 | 111 / 359 | 85% | 28.91 | 244 / 286 |
| esophagus | 51% | 558.64 | 730 / 1445 | 63% | 16.76 | 115 / 183 |
| pancreas | 16% | 115.95 | 51 / 328 | 91% | 36.26 | 162 / 178 |
| lung | 48% | 703.39 | 275 / 578 | 56% | 12.77 | 650 / 1155 |
| skin | 36% | 355.99 | 655 / 1809 | 68% | 27.34 | 319 / 472 |
| spleen | 100% | 11098.93 | 241 / 241 | 0% | 0 | 0 / 0 |
| heart | 94% | 2182.95 | 811 / 861 | 0% | 0 | 0 / 0 |
| bladder | 33% | 481.19 | 7 / 21 | 61% | 13.73 | 305 / 504 |
| adipose | 81% | 2416.93 | 973 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 79% | 15.63 | 23 / 29 |
| uterus | 17% | 181.41 | 29 / 170 | 37% | 8.14 | 169 / 459 |
| tonsil | 0% | 0 | 0 / 0 | 49% | 8.85 | 22 / 45 |
| muscle | 46% | 417.26 | 370 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 42% | 573.63 | 562 / 1335 | 0% | 0 | 0 / 0 |
| ovary | 7% | 74.84 | 12 / 180 | 32% | 5.19 | 139 / 430 |
| prostate | 12% | 80.78 | 29 / 245 | 16% | 2.34 | 78 / 502 |
| eye | 0% | 0 | 0 / 0 | 9% | 1.25 | 7 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0001525 | Biological process | angiogenesis |
| GO_0010468 | Biological process | regulation of gene expression |
| GO_0035886 | Biological process | vascular associated smooth muscle cell differentiation |
| GO_0060841 | Biological process | venous blood vessel development |
| GO_0035904 | Biological process | aorta development |
| GO_0003272 | Biological process | endocardial cushion formation |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_1904325 | Biological process | positive regulation of inhibitory G protein-coupled receptor phosphorylation |
| GO_0007507 | Biological process | heart development |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0001947 | Biological process | heart looping |
| GO_0001570 | Biological process | vasculogenesis |
| GO_0060976 | Biological process | coronary vasculature development |
| GO_0007369 | Biological process | gastrulation |
| GO_0001944 | Biological process | vasculature development |
| GO_1903596 | Biological process | regulation of gap junction assembly |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0050878 | Biological process | regulation of body fluid levels |
| GO_0007512 | Biological process | adult heart development |
| GO_0060412 | Biological process | ventricular septum morphogenesis |
| GO_0001568 | Biological process | blood vessel development |
| GO_0051281 | Biological process | positive regulation of release of sequestered calcium ion into cytosol |
| GO_0043951 | Biological process | negative regulation of cAMP-mediated signaling |
| GO_1903589 | Biological process | positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| GO_0003171 | Biological process | atrioventricular valve development |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0004930 | Molecular function | G protein-coupled receptor activity |
| GO_0060182 | Molecular function | apelin receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | APLNR |
| Protein name | Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11) |
| Synonyms | AGTRL1 APJ |
| Description | FUNCTION: Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity . Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure . .; FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia . . |
| Accessions | ENST00000606794.2 ENST00000257254.3 P35414 |
