PLPPR4 | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	10 studies	48% ± 25%	Explore
GABAergic neuron	8 studies	48% ± 24%	Explore
oligodendrocyte precursor cell	8 studies	28% ± 11%	Explore
interneuron	5 studies	52% ± 25%	Explore
neuron	3 studies	24% ± 7%	Explore
endothelial cell	3 studies	27% ± 7%	Explore

Name	Number of supported studies	Average coverage
brain	8 studies	38% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	95%	2859.41	2507 / 2642	99%	27.27	701 / 705
breast	75%	391.33	344 / 459	69%	1.91	773 / 1118
thymus	72%	323.48	470 / 653	44%	0.93	269 / 605
lung	49%	229.57	286 / 578	64%	2.03	744 / 1155
skin	51%	174.69	916 / 1809	58%	7.55	274 / 472
esophagus	42%	149.51	613 / 1445	66%	2.40	120 / 183
bladder	67%	2233.62	14 / 21	39%	1.12	199 / 504
pancreas	13%	37.23	42 / 328	79%	3.20	140 / 178
adipose	82%	546.10	984 / 1204	0%	0	0 / 0
intestine	27%	89.75	259 / 966	49%	1.43	258 / 527
stomach	10%	29.21	35 / 359	62%	2.74	176 / 286
uterus	23%	68.65	39 / 170	41%	1.11	186 / 459
adrenal gland	2%	6.43	6 / 258	60%	4.86	139 / 230
ovary	4%	14.84	8 / 180	51%	1.78	220 / 430
tonsil	0%	0	0 / 0	53%	1.43	24 / 45
prostate	14%	55.03	34 / 245	30%	0.61	150 / 502
blood vessel	34%	158.78	460 / 1335	0%	0	0 / 0
kidney	0%	0	0 / 89	26%	0.76	238 / 901
lymph node	0%	0	0 / 0	17%	0.24	5 / 29
eye	0%	0	0 / 0	9%	0.30	7 / 80
liver	0%	0	0 / 226	8%	0.18	33 / 406
muscle	6%	17.65	50 / 803	0%	0	0 / 0
heart	6%	20.23	52 / 861	0%	0	0 / 0
spleen	1%	1.88	2 / 241	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007409	Biological process	axonogenesis
GO_0007165	Biological process	signal transduction
GO_0006644	Biological process	phospholipid metabolic process
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0048839	Biological process	inner ear development
GO_0051966	Biological process	regulation of synaptic transmission, glutamatergic
GO_0140354	Biological process	lipid import into cell
GO_0046839	Biological process	phospholipid dephosphorylation
GO_0098978	Cellular component	glutamatergic synapse
GO_0098839	Cellular component	postsynaptic density membrane
GO_0005886	Cellular component	plasma membrane
GO_0008195	Molecular function	phosphatidate phosphatase activity
GO_0052642	Molecular function	lysophosphatidic acid phosphatase activity

Gene name	PLPPR4
Protein name	Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1) LPPR4 protein
Synonyms	PHP1 LPPR4 PRG1 KIAA0455
Description	FUNCTION: Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane (By similarity). Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity). .
Accessions	Q86XM6 Q3ZCT6 ENST00000370185.9 [Q7Z2D5-4] Q7Z2D5

PLPPR4 report