TAFA5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904753Biological processnegative regulation of vascular associated smooth muscle cell migration
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0061044Biological processnegative regulation of vascular wound healing
GO_1904706Biological processnegative regulation of vascular associated smooth muscle cell proliferation
GO_0005615Cellular componentextracellular space
GO_0005737Cellular componentcytoplasm
GO_0005125Molecular functioncytokine activity
GO_0048018Molecular functionreceptor ligand activity
GO_0001664Molecular functionG protein-coupled receptor binding

IV. Literature review

[source]
Gene nameTAFA5
Protein nameTAFA chemokine like family member 5
Chemokine-like protein TAFA-5
SynonymsUNQ5208/PRO34524
FAM19A5
DescriptionFUNCTION: Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2 (By similarity). Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (By similarity). .

AccessionsENST00000402357.6 [Q7Z5A7-1]
ENST00000406880.1 [Q7Z5A7-3]
Q7Z5A7
ENST00000358295.9 [Q7Z5A7-2]
ENST00000336769.9
B1B1J6