RGS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050873Biological processbrown fat cell differentiation
GO_0007283Biological processspermatogenesis
GO_0010976Biological processpositive regulation of neuron projection development
GO_0071877Biological processregulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway
GO_0060452Biological processpositive regulation of cardiac muscle contraction
GO_0060087Biological processrelaxation of vascular associated smooth muscle
GO_0055119Biological processrelaxation of cardiac muscle
GO_0045471Biological processresponse to ethanol
GO_0045744Biological processnegative regulation of G protein-coupled receptor signaling pathway
GO_0010519Biological processnegative regulation of phospholipase activity
GO_0061052Biological processnegative regulation of cell growth involved in cardiac muscle cell development
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_0043407Biological processnegative regulation of MAP kinase activity
GO_0001975Biological processresponse to amphetamine
GO_1900924Biological processnegative regulation of glycine import across plasma membrane
GO_0017148Biological processnegative regulation of translation
GO_0010614Biological processnegative regulation of cardiac muscle hypertrophy
GO_0060135Biological processmaternal process involved in female pregnancy
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0048487Molecular functionbeta-tubulin binding
GO_0001965Molecular functionG-protein alpha-subunit binding
GO_0005096Molecular functionGTPase activator activity
GO_0005516Molecular functioncalmodulin binding
GO_0010855Molecular functionadenylate cyclase inhibitor activity
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRGS2
Protein nameRGS2 protein
Regulator of G-protein signaling 2 (RGS2) (Cell growth-inhibiting gene 31 protein) (G0/G1 switch regulatory protein 8)
SynonymsG0S8
GIG31
DescriptionFUNCTION: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form . It is involved in the negative regulation of the angiotensin-activated signaling pathway . Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein . .

AccessionsQ49A86
P41220
ENST00000235382.7 [P41220-1]