PDE4A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0007165Biological processsignal transduction
GO_0019933Biological processcAMP-mediated signaling
GO_0106070Biological processregulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0007608Biological processsensory perception of smell
GO_0010738Biological processregulation of protein kinase A signaling
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0006198Biological processcAMP catabolic process
GO_0032587Cellular componentruffle membrane
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0030552Molecular functioncAMP binding
GO_0047555Molecular function3',5'-cyclic-GMP phosphodiesterase activity
GO_0046872Molecular functionmetal ion binding
GO_0004115Molecular function3',5'-cyclic-AMP phosphodiesterase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePDE4A
Protein namecAMP specific phosphodiesterase variant PDE4A-10
cAMP specific phosphodiesterase variant TM3
3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A)
3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53)
SynonymsDPDE2
DescriptionFUNCTION: Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. .; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. .; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. .; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. .; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. .; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. .; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. .

AccessionsENST00000589073.1
ENST00000592685.5 [P27815-7]
ENST00000293683.9 [P27815-2]
ENST00000380702.7 [P27815-1]
ENST00000440014.6 [P27815-6]
P27815
K7ENX7
ENST00000591971.5
Q9HC30
K7EKV1
Q9HC31
ENST00000344979.7 [P27815-4]