RAC2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	44 studies	69% ± 20%	Explore
B cell	42 studies	57% ± 21%	Explore
CD8-positive, alpha-beta T cell	39 studies	65% ± 22%	Explore
T cell	34 studies	56% ± 24%	Explore
CD4-positive, alpha-beta T cell	34 studies	64% ± 22%	Explore
regulatory T cell	28 studies	72% ± 19%	Explore
classical monocyte	26 studies	46% ± 20%	Explore
mast cell	24 studies	63% ± 19%	Explore
conventional dendritic cell	23 studies	46% ± 23%	Explore
non-classical monocyte	23 studies	62% ± 20%	Explore
plasmacytoid dendritic cell	22 studies	64% ± 19%	Explore
mature NK T cell	21 studies	68% ± 18%	Explore
macrophage	21 studies	28% ± 12%	Explore
memory B cell	20 studies	71% ± 15%	Explore
naive B cell	20 studies	59% ± 17%	Explore
monocyte	19 studies	42% ± 14%	Explore
gamma-delta T cell	19 studies	68% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	56% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	72% ± 19%	Explore
mucosal invariant T cell	16 studies	62% ± 19%	Explore
plasma cell	16 studies	54% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	80% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	73% ± 17%	Explore
dendritic cell	12 studies	48% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	61% ± 25%	Explore
plasmablast	12 studies	63% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	67% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	69% ± 20%	Explore
T follicular helper cell	10 studies	68% ± 18%	Explore
myeloid cell	10 studies	43% ± 24%	Explore
neutrophil	9 studies	38% ± 19%	Explore
innate lymphoid cell	8 studies	59% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	65% ± 33%	Explore
platelet	7 studies	27% ± 10%	Explore
leukocyte	7 studies	41% ± 8%	Explore
hematopoietic stem cell	7 studies	65% ± 25%	Explore
precursor B cell	7 studies	58% ± 21%	Explore
CD4-positive helper T cell	6 studies	44% ± 18%	Explore
hematopoietic precursor cell	6 studies	66% ± 22%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	73% ± 33%	Explore
immature B cell	6 studies	78% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	69% ± 24%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	68% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	71% ± 12%	Explore
exhausted T cell	5 studies	87% ± 8%	Explore
T-helper 17 cell	5 studies	72% ± 20%	Explore
group 3 innate lymphoid cell	5 studies	74% ± 11%	Explore
double negative thymocyte	5 studies	80% ± 10%	Explore
granulocyte	5 studies	63% ± 19%	Explore
erythrocyte	5 studies	39% ± 16%	Explore
alveolar macrophage	4 studies	25% ± 7%	Explore
IgG plasma cell	4 studies	33% ± 25%	Explore
megakaryocyte	4 studies	39% ± 2%	Explore
pro-B cell	4 studies	50% ± 9%	Explore
germinal center B cell	4 studies	66% ± 24%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	73% ± 30%	Explore
T-helper 1 cell	4 studies	78% ± 16%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	84% ± 12%	Explore
mononuclear phagocyte	3 studies	40% ± 12%	Explore
erythroblast	3 studies	48% ± 20%	Explore
intraepithelial lymphocyte	3 studies	77% ± 8%	Explore
abnormal cell	3 studies	56% ± 11%	Explore
intermediate monocyte	3 studies	71% ± 19%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	74% ± 17%	Explore
double-positive, alpha-beta thymocyte	3 studies	79% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	59% ± 17%	Explore
lung	12 studies	27% ± 10%	Explore
lymph node	5 studies	47% ± 21%	Explore
bone marrow	5 studies	44% ± 26%	Explore
liver	5 studies	33% ± 14%	Explore
intestine	3 studies	30% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	4005.59	578 / 578	97%	91.06	1124 / 1155
bladder	86%	1240.62	18 / 21	90%	63.36	453 / 504
stomach	78%	767.36	279 / 359	95%	70.79	272 / 286
breast	76%	722.87	351 / 459	92%	56.74	1030 / 1118
intestine	68%	2143.53	660 / 966	95%	65.37	502 / 527
esophagus	63%	592.29	906 / 1445	94%	66.14	172 / 183
skin	60%	1182.59	1089 / 1809	83%	84.91	391 / 472
uterus	53%	364.19	90 / 170	90%	62.23	413 / 459
kidney	49%	584.12	44 / 89	84%	45.26	753 / 901
prostate	76%	718.62	187 / 245	52%	15.23	263 / 502
thymus	42%	552.82	273 / 653	82%	119.95	494 / 605
ovary	29%	213.94	53 / 180	80%	29.87	346 / 430
pancreas	10%	74.01	34 / 328	93%	84.11	165 / 178
liver	55%	408.38	124 / 226	48%	25.14	195 / 406
lymph node	0%	0	0 / 0	100%	858.61	29 / 29
peripheral blood	100%	55322.36	929 / 929	0%	0	0 / 0
spleen	100%	19737.00	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	128.06	43 / 45
adipose	91%	1220.94	1091 / 1204	0%	0	0 / 0
adrenal gland	36%	236.60	92 / 258	19%	8.02	44 / 230
blood vessel	44%	471.23	585 / 1335	0%	0	0 / 0
brain	8%	59.46	215 / 2642	34%	11.79	242 / 705
eye	0%	0	0 / 0	36%	14.96	29 / 80
heart	15%	106.18	129 / 861	0%	0	0 / 0
muscle	0%	1.86	3 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0045730	Biological process	respiratory burst
GO_1902622	Biological process	regulation of neutrophil migration
GO_0007165	Biological process	signal transduction
GO_0042129	Biological process	regulation of T cell proliferation
GO_0043304	Biological process	regulation of mast cell degranulation
GO_0010592	Biological process	positive regulation of lamellipodium assembly
GO_0030031	Biological process	cell projection assembly
GO_0010810	Biological process	regulation of cell-substrate adhesion
GO_0006935	Biological process	chemotaxis
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0007264	Biological process	small GTPase-mediated signal transduction
GO_0007015	Biological process	actin filament organization
GO_0060753	Biological process	regulation of mast cell chemotaxis
GO_0045453	Biological process	bone resorption
GO_0060263	Biological process	regulation of respiratory burst
GO_0071593	Biological process	lymphocyte aggregation
GO_0090023	Biological process	positive regulation of neutrophil chemotaxis
GO_1903955	Biological process	positive regulation of protein targeting to mitochondrion
GO_0010310	Biological process	regulation of hydrogen peroxide metabolic process
GO_0070668	Biological process	positive regulation of mast cell proliferation
GO_0043131	Biological process	erythrocyte enucleation
GO_0070662	Biological process	mast cell proliferation
GO_0005886	Cellular component	plasma membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0070062	Cellular component	extracellular exosome
GO_0043020	Cellular component	NADPH oxidase complex
GO_0005635	Cellular component	nuclear envelope
GO_0005884	Cellular component	actin filament
GO_0005925	Cellular component	focal adhesion
GO_0005829	Cellular component	cytosol
GO_0030670	Cellular component	phagocytic vesicle membrane
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0030027	Cellular component	lamellipodium
GO_0019887	Molecular function	protein kinase regulator activity
GO_0005525	Molecular function	GTP binding
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	RAC2
Protein name	Rac family small GTPase 2 (Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2), isoform CRA_d) Rac family small GTPase 2 Rac family small GTPase 2 (Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2), isoform CRA_c) Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Synonyms	hCG_1811995
Description	FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. .
Accessions	P15153 ENST00000441619.5 ENST00000401529.3 ENST00000249071.11 ENST00000406508.5 B1AH77 B1AH78 B1AH80 B1AH79 ENST00000405484.5

RAC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review