ADGRV1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	15 studies	70% ± 27%	Explore
glutamatergic neuron	8 studies	39% ± 21%	Explore
retinal cone cell	7 studies	71% ± 23%	Explore
retinal rod cell	7 studies	49% ± 30%	Explore
ciliated cell	7 studies	33% ± 18%	Explore
club cell	5 studies	38% ± 21%	Explore
type I pneumocyte	5 studies	44% ± 9%	Explore
type II pneumocyte	5 studies	56% ± 7%	Explore
GABAergic neuron	4 studies	41% ± 20%	Explore
endothelial cell	3 studies	22% ± 2%	Explore
epithelial cell	3 studies	37% ± 19%	Explore
retinal bipolar neuron	3 studies	31% ± 8%	Explore
ON-bipolar cell	3 studies	34% ± 17%	Explore
amacrine cell	3 studies	20% ± 5%	Explore
microglial cell	3 studies	42% ± 18%	Explore
rod bipolar cell	3 studies	39% ± 24%	Explore
respiratory goblet cell	3 studies	40% ± 18%	Explore
granule cell	3 studies	23% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	10 studies	32% ± 13%	Explore
eye	7 studies	34% ± 19%	Explore
lung	3 studies	28% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	86%	4787.49	2280 / 2642	94%	12.89	663 / 705
adrenal gland	100%	37803.78	258 / 258	39%	3.33	90 / 230
thymus	99%	3633.49	648 / 653	30%	0.94	184 / 605
lung	63%	655.09	366 / 578	56%	2.00	648 / 1155
breast	46%	476.29	212 / 459	56%	2.66	626 / 1118
prostate	37%	234.51	90 / 245	61%	1.28	308 / 502
liver	46%	349.72	104 / 226	43%	1.23	174 / 406
bladder	29%	242.62	6 / 21	37%	0.98	188 / 504
tonsil	0%	0	0 / 0	58%	1.24	26 / 45
pancreas	29%	166.09	96 / 328	12%	0.42	22 / 178
esophagus	2%	7.87	22 / 1445	30%	0.58	55 / 183
uterus	1%	3.72	1 / 170	30%	0.72	137 / 459
kidney	19%	148.28	17 / 89	3%	0.07	28 / 901
skin	1%	7.56	27 / 1809	9%	0.36	44 / 472
ovary	0%	0	0 / 180	7%	0.12	28 / 430
stomach	1%	5.32	3 / 359	5%	0.10	14 / 286
intestine	0%	1.43	1 / 966	3%	0.09	17 / 527
peripheral blood	2%	25.56	19 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.02	1 / 80
muscle	1%	10.01	9 / 803	0%	0	0 / 0
blood vessel	0%	2.20	2 / 1335	0%	0	0 / 0
heart	0%	0.57	1 / 861	0%	0	0 / 0
adipose	0%	0.67	1 / 1204	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007194	Biological process	negative regulation of adenylate cyclase activity
GO_0007601	Biological process	visual perception
GO_0007605	Biological process	sensory perception of sound
GO_0048496	Biological process	maintenance of animal organ identity
GO_0045184	Biological process	establishment of protein localization
GO_0045494	Biological process	photoreceptor cell maintenance
GO_0060122	Biological process	inner ear receptor cell stereocilium organization
GO_0048839	Biological process	inner ear development
GO_0071277	Biological process	cellular response to calcium ion
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0010739	Biological process	positive regulation of protein kinase A signaling
GO_0097264	Biological process	self proteolysis
GO_0050953	Biological process	sensory perception of light stimulus
GO_0090037	Biological process	positive regulation of protein kinase C signaling
GO_0060113	Biological process	inner ear receptor cell differentiation
GO_0050910	Biological process	detection of mechanical stimulus involved in sensory perception of sound
GO_0098609	Biological process	cell-cell adhesion
GO_0030501	Biological process	positive regulation of bone mineralization
GO_0050877	Biological process	nervous system process
GO_0007399	Biological process	nervous system development
GO_0031647	Biological process	regulation of protein stability
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_1990075	Cellular component	periciliary membrane compartment
GO_0032420	Cellular component	stereocilium
GO_0043235	Cellular component	receptor complex
GO_0002141	Cellular component	stereocilia ankle link
GO_0005886	Cellular component	plasma membrane
GO_0060171	Cellular component	stereocilium membrane
GO_0016020	Cellular component	membrane
GO_0002142	Cellular component	stereocilia ankle link complex
GO_0070062	Cellular component	extracellular exosome
GO_0001917	Cellular component	photoreceptor inner segment
GO_0009986	Cellular component	cell surface
GO_0005737	Cellular component	cytoplasm
GO_1990696	Cellular component	USH2 complex
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0016787	Molecular function	hydrolase activity
GO_0001965	Molecular function	G-protein alpha-subunit binding
GO_0005509	Molecular function	calcium ion binding
GO_0010855	Molecular function	adenylate cyclase inhibitor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ADGRV1
Protein name	Alternative protein GPR98 Adhesion G protein-coupled receptor V1 Adhesion G-protein coupled receptor V1 (ADGRV1) (EC 3.4.-.-) (G-protein coupled receptor 98) (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Usher syndrome type-2C protein) (Very large G-protein coupled receptor 1) [Cleaved into: ADGRV1 subunit alpha; ADGRV1 subunit beta]
Synonyms	VLGR1 KIAA1943 GPR98 MASS1 KIAA0686
Description	FUNCTION: G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Involved in the regulation of bone metabolism. .; FUNCTION: [ADGRV1 subunit beta]: Cleaved ADGRV1 beta-subunit couples with G-alpha(i)-proteins, GNAI1/2/3, and constitutively inhibits adenylate cyclase (AC) activity with a stronger effect than full ADGRV1. .
Accessions	A0A1W2PRR5 L8EBA1 ENST00000638990.1 ENST00000640779.1 D6RIF0 ENST00000639431.1 A0A1W2PQU5 A0A1W2PQK7 ENST00000640407.1 A0A1W2PS99 Q8WXG9 A0A1W2PS08 A0A1W2PPA4 ENST00000508842.5 ENST00000640815.1 A0A1X7SBU6 ENST00000405460.9 [Q8WXG9-1] A0A1W2PR51 A0A1W2PRC7 ENST00000639821.1 ENST00000640012.1 ENST00000640403.1 ENST00000640369.1 ENST00000425867.3 ENST00000638975.1 A0A1W2PP32 A0A1W2PR84 A0A1W2PQP9 A0A1W2PNS5 ENST00000507314.2 ENST00000639707.1 ENST00000450321.2

ADGRV1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review