Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 17 studies | 54% ± 18% | |
pericyte | 17 studies | 22% ± 6% | |
endothelial cell | 15 studies | 25% ± 11% | |
fibroblast | 13 studies | 26% ± 9% | |
glutamatergic neuron | 10 studies | 40% ± 23% | |
oligodendrocyte precursor cell | 10 studies | 27% ± 13% | |
epithelial cell | 7 studies | 29% ± 7% | |
adipocyte | 7 studies | 41% ± 16% | |
GABAergic neuron | 7 studies | 45% ± 20% | |
kidney loop of Henle epithelial cell | 6 studies | 25% ± 6% | |
myofibroblast cell | 6 studies | 24% ± 7% | |
neuron | 6 studies | 32% ± 14% | |
interneuron | 6 studies | 49% ± 20% | |
basal cell | 5 studies | 32% ± 11% | |
ciliated cell | 5 studies | 27% ± 5% | |
smooth muscle cell | 5 studies | 21% ± 3% | |
retina horizontal cell | 5 studies | 28% ± 10% | |
mast cell | 5 studies | 31% ± 12% | |
amacrine cell | 4 studies | 23% ± 6% | |
astrocyte | 4 studies | 33% ± 25% | |
pancreatic A cell | 3 studies | 42% ± 19% | |
progenitor cell | 3 studies | 24% ± 3% | |
GABAergic interneuron | 3 studies | 26% ± 3% | |
granule cell | 3 studies | 26% ± 6% | |
Mueller cell | 3 studies | 18% ± 3% | |
secretory cell | 3 studies | 24% ± 4% | |
connective tissue cell | 3 studies | 36% ± 6% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 18% ± 1% | |
keratinocyte | 3 studies | 27% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 99% | 3965.43 | 2620 / 2642 | 91% | 8.07 | 642 / 705 |
adrenal gland | 100% | 3513.00 | 258 / 258 | 89% | 5.23 | 204 / 230 |
kidney | 98% | 2511.33 | 87 / 89 | 88% | 6.81 | 795 / 901 |
uterus | 100% | 2065.75 | 170 / 170 | 84% | 5.98 | 387 / 459 |
prostate | 93% | 1328.08 | 227 / 245 | 90% | 6.51 | 451 / 502 |
lung | 99% | 2129.67 | 572 / 578 | 77% | 4.71 | 886 / 1155 |
esophagus | 100% | 3359.35 | 1444 / 1445 | 74% | 5.47 | 135 / 183 |
skin | 100% | 5118.03 | 1808 / 1809 | 68% | 3.65 | 320 / 472 |
bladder | 100% | 3489.43 | 21 / 21 | 66% | 3.96 | 331 / 504 |
liver | 88% | 1020.89 | 199 / 226 | 70% | 3.56 | 285 / 406 |
thymus | 99% | 2111.76 | 645 / 653 | 59% | 2.86 | 359 / 605 |
ovary | 99% | 2347.14 | 179 / 180 | 50% | 1.77 | 215 / 430 |
breast | 100% | 4529.09 | 458 / 459 | 36% | 1.35 | 404 / 1118 |
intestine | 97% | 2876.83 | 939 / 966 | 38% | 1.43 | 199 / 527 |
stomach | 99% | 2076.42 | 357 / 359 | 33% | 1.22 | 94 / 286 |
adipose | 100% | 6052.59 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 2691.77 | 1323 / 1335 | 0% | 0 | 0 / 0 |
pancreas | 12% | 101.66 | 39 / 328 | 86% | 4.41 | 153 / 178 |
tonsil | 0% | 0 | 0 / 0 | 93% | 6.69 | 42 / 45 |
eye | 0% | 0 | 0 / 0 | 65% | 3.54 | 52 / 80 |
spleen | 62% | 666.01 | 150 / 241 | 0% | 0 | 0 / 0 |
heart | 51% | 475.68 | 437 / 861 | 0% | 0 | 0 / 0 |
muscle | 24% | 195.88 | 189 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007188 | Biological process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
GO_0043434 | Biological process | response to peptide hormone |
GO_0051301 | Biological process | cell division |
GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
GO_0007193 | Biological process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
GO_1904322 | Biological process | cellular response to forskolin |
GO_0043949 | Biological process | regulation of cAMP-mediated signaling |
GO_1904778 | Biological process | positive regulation of protein localization to cell cortex |
GO_0060236 | Biological process | regulation of mitotic spindle organization |
GO_0005730 | Cellular component | nucleolus |
GO_0030496 | Cellular component | midbody |
GO_0005886 | Cellular component | plasma membrane |
GO_0005813 | Cellular component | centrosome |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005938 | Cellular component | cell cortex |
GO_0005737 | Cellular component | cytoplasm |
GO_0005834 | Cellular component | heterotrimeric G-protein complex |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0019003 | Molecular function | GDP binding |
GO_0031683 | Molecular function | G-protein beta/gamma-subunit complex binding |
GO_0031821 | Molecular function | G protein-coupled serotonin receptor binding |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0001664 | Molecular function | G protein-coupled receptor binding |
GO_0005525 | Molecular function | GTP binding |
GO_0031749 | Molecular function | D2 dopamine receptor binding |
GO_0005515 | Molecular function | protein binding |
GO_0003924 | Molecular function | GTPase activity |
Gene name | GNAI1 |
Protein name | Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein) Uncharacterized protein GNAI1 G protein subunit alpha i1 |
Synonyms | |
Description | FUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins . Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis . Required for cortical dynein-dynactin complex recruitment during metaphase . . |
Accessions | P63096 ENST00000649214.1 A0A3B3ITG4 A0A3B3IU77 A0A3B3IUA8 ENST00000351004.8 [P63096-1] O43383 ENST00000648306.1 [P63096-1] ENST00000648375.1 ENST00000648098.1 [P63096-1] A0A3B3ITX3 ENST00000649922.1 ENST00000650431.1 ENST00000649487.1 [P63096-1] ENST00000457358.7 [P63096-2] ENST00000647742.1 ENST00000649855.1 [P63096-1] ENST00000648663.1 [P63096-1] A0A3B3ITM0 ENST00000648953.1 [P63096-1] ENST00000648412.1 [P63096-1] ENST00000649267.1 [P63096-1] A0A3B3IRK0 ENST00000648476.1 [P63096-1] ENST00000648832.1 [P63096-1] ENST00000649225.1 [P63096-1] ENST00000648877.1 [P63096-1] ENST00000649634.1 ENST00000649796.2 [P63096-1] ENST00000442586.2 [P63096-1] ENST00000647672.1 A0A3B3IS42 |