GNAI1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007188Biological processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0043434Biological processresponse to peptide hormone
GO_0051301Biological processcell division
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_1904322Biological processcellular response to forskolin
GO_0043949Biological processregulation of cAMP-mediated signaling
GO_1904778Biological processpositive regulation of protein localization to cell cortex
GO_0060236Biological processregulation of mitotic spindle organization
GO_0005730Cellular componentnucleolus
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005938Cellular componentcell cortex
GO_0005737Cellular componentcytoplasm
GO_0005834Cellular componentheterotrimeric G-protein complex
GO_0005765Cellular componentlysosomal membrane
GO_0019003Molecular functionGDP binding
GO_0031683Molecular functionG-protein beta/gamma-subunit complex binding
GO_0031821Molecular functionG protein-coupled serotonin receptor binding
GO_0000287Molecular functionmagnesium ion binding
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0005525Molecular functionGTP binding
GO_0031749Molecular functionD2 dopamine receptor binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameGNAI1
Protein nameGuanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)
Uncharacterized protein GNAI1
G protein subunit alpha i1
Synonyms
DescriptionFUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins . Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis . Required for cortical dynein-dynactin complex recruitment during metaphase . .

AccessionsP63096
ENST00000649214.1
A0A3B3ITG4
A0A3B3IU77
A0A3B3IUA8
ENST00000351004.8 [P63096-1]
O43383
ENST00000648306.1 [P63096-1]
ENST00000648375.1
ENST00000648098.1 [P63096-1]
A0A3B3ITX3
ENST00000649922.1
ENST00000650431.1
ENST00000649487.1 [P63096-1]
ENST00000457358.7 [P63096-2]
ENST00000647742.1
ENST00000649855.1 [P63096-1]
ENST00000648663.1 [P63096-1]
A0A3B3ITM0
ENST00000648953.1 [P63096-1]
ENST00000648412.1 [P63096-1]
ENST00000649267.1 [P63096-1]
A0A3B3IRK0
ENST00000648476.1 [P63096-1]
ENST00000648832.1 [P63096-1]
ENST00000649225.1 [P63096-1]
ENST00000648877.1 [P63096-1]
ENST00000649634.1
ENST00000649796.2 [P63096-1]
ENST00000442586.2 [P63096-1]
ENST00000647672.1
A0A3B3IS42