Insufficient scRNA-seq data for expression of SMO at tissue level.
Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 3661.69 | 245 / 245 | 100% | 36.84 | 501 / 502 |
| ovary | 100% | 4773.38 | 180 / 180 | 97% | 36.72 | 415 / 430 |
| kidney | 100% | 2297.30 | 89 / 89 | 94% | 38.31 | 844 / 901 |
| liver | 98% | 2027.19 | 222 / 226 | 94% | 35.72 | 380 / 406 |
| thymus | 100% | 1731.27 | 653 / 653 | 91% | 21.90 | 552 / 605 |
| brain | 92% | 761.42 | 2437 / 2642 | 97% | 33.84 | 686 / 705 |
| skin | 97% | 1787.21 | 1751 / 1809 | 83% | 34.91 | 392 / 472 |
| pancreas | 95% | 614.86 | 312 / 328 | 81% | 13.54 | 145 / 178 |
| uterus | 100% | 4092.58 | 170 / 170 | 75% | 27.05 | 344 / 459 |
| breast | 93% | 1061.49 | 426 / 459 | 81% | 18.10 | 910 / 1118 |
| esophagus | 100% | 1794.32 | 1444 / 1445 | 61% | 19.20 | 111 / 183 |
| bladder | 100% | 1605.33 | 21 / 21 | 56% | 11.01 | 280 / 504 |
| lung | 82% | 623.76 | 474 / 578 | 68% | 20.88 | 789 / 1155 |
| stomach | 94% | 922.58 | 336 / 359 | 55% | 8.80 | 158 / 286 |
| intestine | 98% | 1317.66 | 943 / 966 | 43% | 6.25 | 227 / 527 |
| adrenal gland | 98% | 1014.94 | 254 / 258 | 19% | 3.15 | 43 / 230 |
| eye | 0% | 0 | 0 / 0 | 100% | 46.40 | 80 / 80 |
| ureter | 0% | 0 | 0 / 0 | 100% | 10.85 | 1 / 1 |
| blood vessel | 94% | 995.60 | 1255 / 1335 | 0% | 0 | 0 / 0 |
| heart | 94% | 822.90 | 807 / 861 | 0% | 0 | 0 / 0 |
| spleen | 91% | 468.00 | 219 / 241 | 0% | 0 | 0 / 0 |
| adipose | 88% | 752.16 | 1057 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 69% | 12.06 | 31 / 45 |
| muscle | 49% | 224.81 | 390 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 38% | 3.87 | 11 / 29 |
| peripheral blood | 16% | 148.38 | 148 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0021794 | Biological process | thalamus development |
| GO_0002052 | Biological process | positive regulation of neuroblast proliferation |
| GO_0001947 | Biological process | heart looping |
| GO_0048741 | Biological process | skeletal muscle fiber development |
| GO_0035264 | Biological process | multicellular organism growth |
| GO_2000826 | Biological process | regulation of heart morphogenesis |
| GO_0001933 | Biological process | negative regulation of protein phosphorylation |
| GO_0002053 | Biological process | positive regulation of mesenchymal cell proliferation |
| GO_0030857 | Biological process | negative regulation of epithelial cell differentiation |
| GO_0021696 | Biological process | cerebellar cortex morphogenesis |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0050821 | Biological process | protein stabilization |
| GO_0061113 | Biological process | pancreas morphogenesis |
| GO_0003323 | Biological process | type B pancreatic cell development |
| GO_0007417 | Biological process | central nervous system development |
| GO_0021513 | Biological process | spinal cord dorsal/ventral patterning |
| GO_0048853 | Biological process | forebrain morphogenesis |
| GO_0042475 | Biological process | odontogenesis of dentin-containing tooth |
| GO_0050673 | Biological process | epithelial cell proliferation |
| GO_0007224 | Biological process | smoothened signaling pathway |
| GO_0070986 | Biological process | left/right axis specification |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0001755 | Biological process | neural crest cell migration |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0048143 | Biological process | astrocyte activation |
| GO_0001649 | Biological process | osteoblast differentiation |
| GO_0007494 | Biological process | midgut development |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0042307 | Biological process | positive regulation of protein import into nucleus |
| GO_0051799 | Biological process | negative regulation of hair follicle development |
| GO_0050679 | Biological process | positive regulation of epithelial cell proliferation |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0071397 | Biological process | cellular response to cholesterol |
| GO_0060644 | Biological process | mammary gland epithelial cell differentiation |
| GO_0006606 | Biological process | protein import into nucleus |
| GO_0043392 | Biological process | negative regulation of DNA binding |
| GO_0010467 | Biological process | gene expression |
| GO_0003140 | Biological process | determination of left/right asymmetry in lateral mesoderm |
| GO_0040018 | Biological process | positive regulation of multicellular organism growth |
| GO_0048745 | Biological process | smooth muscle tissue development |
| GO_0007405 | Biological process | neuroblast proliferation |
| GO_0001708 | Biological process | cell fate specification |
| GO_0007371 | Biological process | ventral midline determination |
| GO_1904672 | Biological process | regulation of somatic stem cell population maintenance |
| GO_0061053 | Biological process | somite development |
| GO_0060242 | Biological process | contact inhibition |
| GO_0031069 | Biological process | hair follicle morphogenesis |
| GO_0021542 | Biological process | dentate gyrus development |
| GO_0021953 | Biological process | central nervous system neuron differentiation |
| GO_0001570 | Biological process | vasculogenesis |
| GO_0090190 | Biological process | positive regulation of branching involved in ureteric bud morphogenesis |
| GO_0009952 | Biological process | anterior/posterior pattern specification |
| GO_0046622 | Biological process | positive regulation of organ growth |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0060413 | Biological process | atrial septum morphogenesis |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0071542 | Biological process | dopaminergic neuron differentiation |
| GO_0021904 | Biological process | dorsal/ventral neural tube patterning |
| GO_0048873 | Biological process | homeostasis of number of cells within a tissue |
| GO_0045880 | Biological process | positive regulation of smoothened signaling pathway |
| GO_0071679 | Biological process | commissural neuron axon guidance |
| GO_0072285 | Biological process | mesenchymal to epithelial transition involved in metanephric renal vesicle formation |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0060684 | Biological process | epithelial-mesenchymal cell signaling |
| GO_0006915 | Biological process | apoptotic process |
| GO_0021987 | Biological process | cerebral cortex development |
| GO_0051451 | Biological process | myoblast migration |
| GO_0007389 | Biological process | pattern specification process |
| GO_0097731 | Cellular component | 9+0 non-motile cilium |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0030425 | Cellular component | dendrite |
| GO_0005814 | Cellular component | centriole |
| GO_0060170 | Cellular component | ciliary membrane |
| GO_0005770 | Cellular component | late endosome |
| GO_0005793 | Cellular component | endoplasmic reticulum-Golgi intermediate compartment |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030666 | Cellular component | endocytic vesicle membrane |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005929 | Cellular component | cilium |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005901 | Cellular component | caveola |
| GO_0097542 | Cellular component | ciliary tip |
| GO_0004862 | Molecular function | cAMP-dependent protein kinase inhibitor activity |
| GO_0034236 | Molecular function | protein kinase A catalytic subunit binding |
| GO_0140311 | Molecular function | protein sequestering activity |
| GO_0005113 | Molecular function | patched binding |
| GO_0004930 | Molecular function | G protein-coupled receptor activity |
| GO_0008142 | Molecular function | oxysterol binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SMO |
| Protein name | Protein smoothened (Protein Gx) Smoothened frizzled class receptor Smoothened, frizzled class receptor |
| Synonyms | SMOH |
| Description | FUNCTION: G protein-coupled receptor which associates with the patched protein (PTCH) to transduce hedgehog protein signaling. Binding of sonic hedgehog (SHH) to its receptor patched prevents inhibition of smoothened (SMO) by patched. When active, SMO binds to and sequesters protein kinase A catalytic subunit PRKACA at the cell membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors which releases the GLI proteins from PRKACA-mediated inhibition and allows for transcriptional activation of hedgehog pathway target genes (By similarity). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia . Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). . |
| Accessions | H7C509 ENST00000475779.1 A0A6M5WQP3 ENST00000655644.1 A0A590UJE7 H7C5S9 ENST00000462420.2 ENST00000249373.8 Q99835 |
