GPR171 | OmnibusX

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	17 studies	26% ± 7%	Explore
CD8-positive, alpha-beta T cell	17 studies	22% ± 7%	Explore
T cell	12 studies	22% ± 8%	Explore
mucosal invariant T cell	10 studies	22% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	23% ± 6%	Explore
gamma-delta T cell	7 studies	32% ± 12%	Explore
mature NK T cell	6 studies	25% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	23% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	21% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	23% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	22% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	24% ± 4%	Explore
CD4-positive helper T cell	3 studies	32% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	21% ± 2%	Explore
T follicular helper cell	3 studies	23% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR171 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	99%	312.81	575 / 578	89%	7.27	1024 / 1155
stomach	98%	128.35	352 / 359	73%	4.04	208 / 286
intestine	85%	210.79	824 / 966	67%	2.63	351 / 527
uterus	76%	46.66	129 / 170	70%	3.86	320 / 459
thymus	87%	94.04	568 / 653	53%	2.22	319 / 605
prostate	83%	92.96	203 / 245	55%	1.70	277 / 502
breast	70%	51.34	323 / 459	66%	3.35	738 / 1118
bladder	76%	119.10	16 / 21	58%	2.32	293 / 504
kidney	63%	69.89	56 / 89	71%	2.92	641 / 901
esophagus	61%	41.58	885 / 1445	70%	3.18	129 / 183
pancreas	32%	13.12	105 / 328	78%	4.52	139 / 178
spleen	100%	720.41	241 / 241	0%	0	0 / 0
liver	60%	32.27	136 / 226	38%	1.33	155 / 406
skin	34%	17.88	619 / 1809	58%	4.02	276 / 472
peripheral blood	93%	274.50	860 / 929	0%	0	0 / 0
adipose	92%	114.99	1112 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	14.70	26 / 29
tonsil	0%	0	0 / 0	84%	6.12	38 / 45
ovary	37%	20.54	66 / 180	47%	1.29	202 / 430
adrenal gland	54%	25.15	139 / 258	15%	0.37	35 / 230
blood vessel	52%	43.95	691 / 1335	0%	0	0 / 0
heart	33%	17.22	288 / 861	0%	0	0 / 0
brain	6%	2.15	150 / 2642	10%	0.27	68 / 705
eye	0%	0	0 / 0	9%	0.32	7 / 80
muscle	3%	1.49	25 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0045638	Biological process	negative regulation of myeloid cell differentiation
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0007218	Biological process	neuropeptide signaling pathway
GO_0060259	Biological process	regulation of feeding behavior
GO_0051930	Biological process	regulation of sensory perception of pain
GO_0007188	Biological process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0035589	Biological process	G protein-coupled purinergic nucleotide receptor signaling pathway
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0008528	Molecular function	G protein-coupled peptide receptor activity
GO_0042923	Molecular function	neuropeptide binding
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0008188	Molecular function	neuropeptide receptor activity
GO_0045028	Molecular function	G protein-coupled purinergic nucleotide receptor activity

Gene name	GPR171
Protein name	G protein-coupled receptor 171 G-protein coupled receptor 171 (G-protein coupled receptor H963)
Synonyms	H963
Description	FUNCTION: G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception (By similarity). Acts as a negative regulator T cell function . .
Accessions	ENST00000309180.6 C9JR91 O14626 ENST00000480322.1 ENST00000617554.1

GPR171 report