CALM3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	34 studies	40% ± 15%	Explore
macrophage	33 studies	37% ± 14%	Explore
CD8-positive, alpha-beta T cell	33 studies	42% ± 22%	Explore
endothelial cell	28 studies	32% ± 15%	Explore
CD4-positive, alpha-beta T cell	28 studies	45% ± 21%	Explore
B cell	27 studies	30% ± 13%	Explore
T cell	27 studies	42% ± 18%	Explore
regulatory T cell	27 studies	50% ± 17%	Explore
fibroblast	26 studies	35% ± 17%	Explore
classical monocyte	23 studies	40% ± 15%	Explore
conventional dendritic cell	23 studies	29% ± 14%	Explore
smooth muscle cell	22 studies	35% ± 14%	Explore
non-classical monocyte	22 studies	49% ± 15%	Explore
pericyte	22 studies	39% ± 17%	Explore
mature NK T cell	18 studies	32% ± 10%	Explore
mast cell	17 studies	38% ± 15%	Explore
monocyte	17 studies	42% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	37% ± 11%	Explore
dendritic cell	17 studies	37% ± 20%	Explore
gamma-delta T cell	17 studies	38% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	35% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	39% ± 11%	Explore
connective tissue cell	15 studies	38% ± 19%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	40% ± 14%	Explore
ciliated cell	14 studies	36% ± 18%	Explore
naive B cell	14 studies	21% ± 7%	Explore
epithelial cell	14 studies	45% ± 21%	Explore
memory B cell	13 studies	24% ± 5%	Explore
myeloid cell	13 studies	43% ± 18%	Explore
plasma cell	12 studies	36% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	40% ± 20%	Explore
glutamatergic neuron	12 studies	53% ± 19%	Explore
endothelial cell of lymphatic vessel	11 studies	29% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	42% ± 20%	Explore
plasmablast	10 studies	51% ± 21%	Explore
platelet	10 studies	71% ± 14%	Explore
capillary endothelial cell	10 studies	22% ± 10%	Explore
myofibroblast cell	10 studies	43% ± 13%	Explore
mucosal invariant T cell	10 studies	32% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	35% ± 14%	Explore
abnormal cell	9 studies	35% ± 14%	Explore
neuron	9 studies	54% ± 24%	Explore
GABAergic neuron	9 studies	41% ± 19%	Explore
astrocyte	9 studies	25% ± 10%	Explore
progenitor cell	8 studies	50% ± 18%	Explore
T follicular helper cell	8 studies	44% ± 9%	Explore
erythrocyte	8 studies	38% ± 22%	Explore
oligodendrocyte	8 studies	22% ± 6%	Explore
oligodendrocyte precursor cell	8 studies	31% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	53% ± 21%	Explore
leukocyte	7 studies	35% ± 16%	Explore
epithelial cell of proximal tubule	7 studies	37% ± 18%	Explore
enterocyte	7 studies	43% ± 18%	Explore
vein endothelial cell	7 studies	30% ± 15%	Explore
precursor B cell	7 studies	38% ± 14%	Explore
endothelial cell of vascular tree	7 studies	25% ± 9%	Explore
innate lymphoid cell	7 studies	30% ± 7%	Explore
basal cell	7 studies	36% ± 20%	Explore
microglial cell	7 studies	20% ± 5%	Explore
hematopoietic precursor cell	6 studies	39% ± 16%	Explore
plasmacytoid dendritic cell	6 studies	27% ± 7%	Explore
megakaryocyte	6 studies	65% ± 28%	Explore
retinal ganglion cell	6 studies	68% ± 34%	Explore
hematopoietic stem cell	6 studies	39% ± 22%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	45% ± 24%	Explore
interneuron	6 studies	44% ± 18%	Explore
CD4-positive helper T cell	5 studies	22% ± 7%	Explore
exhausted T cell	5 studies	59% ± 18%	Explore
mononuclear phagocyte	5 studies	32% ± 18%	Explore
kidney loop of Henle epithelial cell	5 studies	19% ± 1%	Explore
renal alpha-intercalated cell	5 studies	41% ± 8%	Explore
erythroblast	5 studies	41% ± 26%	Explore
goblet cell	5 studies	39% ± 12%	Explore
mesothelial cell	5 studies	47% ± 16%	Explore
amacrine cell	5 studies	56% ± 22%	Explore
pro-B cell	5 studies	42% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	57% ± 23%	Explore
granulocyte	5 studies	35% ± 12%	Explore
alveolar macrophage	4 studies	20% ± 2%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	50% ± 24%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	26% ± 11%	Explore
deuterosomal cell	4 studies	51% ± 9%	Explore
endothelial cell of artery	4 studies	25% ± 11%	Explore
enteroendocrine cell	4 studies	52% ± 14%	Explore
transit amplifying cell	4 studies	40% ± 19%	Explore
retinal rod cell	4 studies	26% ± 7%	Explore
retina horizontal cell	4 studies	35% ± 15%	Explore
germinal center B cell	4 studies	37% ± 11%	Explore
intermediate monocyte	4 studies	57% ± 16%	Explore
group 3 innate lymphoid cell	4 studies	43% ± 13%	Explore
T-helper 17 cell	4 studies	49% ± 27%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	32% ± 4%	Explore
squamous epithelial cell	3 studies	34% ± 26%	Explore
pancreatic A cell	3 studies	62% ± 12%	Explore
type B pancreatic cell	3 studies	43% ± 10%	Explore
glomerular endothelial cell	3 studies	23% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	44% ± 10%	Explore
neural crest cell	3 studies	52% ± 21%	Explore
retinal bipolar neuron	3 studies	46% ± 15%	Explore
GABAergic interneuron	3 studies	30% ± 15%	Explore
OFF-bipolar cell	3 studies	58% ± 31%	Explore
ON-bipolar cell	3 studies	56% ± 32%	Explore
GABAergic amacrine cell	3 studies	54% ± 18%	Explore
glycinergic amacrine cell	3 studies	39% ± 15%	Explore
extravillous trophoblast	3 studies	46% ± 22%	Explore
club cell	3 studies	29% ± 8%	Explore
immature B cell	3 studies	30% ± 5%	Explore
type I pneumocyte	3 studies	35% ± 12%	Explore
type II pneumocyte	3 studies	39% ± 15%	Explore
retinal cone cell	3 studies	44% ± 14%	Explore
intraepithelial lymphocyte	3 studies	44% ± 14%	Explore
Mueller cell	3 studies	29% ± 8%	Explore
neutrophil	3 studies	24% ± 2%	Explore
brush cell	3 studies	22% ± 4%	Explore
granule cell	3 studies	30% ± 11%	Explore
T-helper 1 cell	3 studies	58% ± 24%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	39% ± 14%	Explore
double negative thymocyte	3 studies	54% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	26% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	39% ± 11%	Explore
brain	17 studies	35% ± 16%	Explore
lung	15 studies	34% ± 15%	Explore
intestine	10 studies	34% ± 18%	Explore
eye	8 studies	32% ± 11%	Explore
kidney	7 studies	37% ± 8%	Explore
liver	6 studies	36% ± 24%	Explore
lymph node	6 studies	36% ± 9%	Explore
bone marrow	5 studies	29% ± 8%	Explore
uterus	4 studies	36% ± 14%	Explore
pancreas	3 studies	48% ± 16%	Explore
placenta	3 studies	36% ± 16%	Explore
adrenal gland	3 studies	35% ± 8%	Explore
breast	3 studies	24% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	12970.54	966 / 966	100%	168.90	527 / 527
ovary	100%	14043.99	180 / 180	100%	142.49	430 / 430
brain	100%	55845.26	2639 / 2642	100%	283.07	705 / 705
uterus	100%	14078.22	170 / 170	100%	154.95	458 / 459
kidney	100%	12053.79	89 / 89	100%	159.86	897 / 901
prostate	100%	11663.30	244 / 245	100%	154.14	501 / 502
esophagus	99%	9591.49	1436 / 1445	100%	123.77	183 / 183
adrenal gland	100%	12826.85	258 / 258	99%	203.86	228 / 230
bladder	100%	13017.57	21 / 21	99%	143.81	499 / 504
thymus	99%	9453.60	644 / 653	100%	162.73	604 / 605
breast	99%	8840.52	455 / 459	99%	132.72	1108 / 1118
lung	99%	9880.58	570 / 578	99%	116.30	1144 / 1155
stomach	92%	9182.76	331 / 359	100%	175.44	285 / 286
skin	88%	10392.55	1599 / 1809	100%	163.69	472 / 472
liver	81%	4910.00	183 / 226	99%	94.30	402 / 406
pancreas	77%	4601.37	252 / 328	100%	128.91	178 / 178
eye	0%	0	0 / 0	100%	172.41	80 / 80
lymph node	0%	0	0 / 0	100%	215.23	29 / 29
spleen	100%	9023.85	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	125.86	45 / 45
ureter	0%	0	0 / 0	100%	60.61	1 / 1
blood vessel	100%	19017.81	1334 / 1335	0%	0	0 / 0
muscle	99%	10442.86	791 / 803	0%	0	0 / 0
adipose	98%	9137.75	1183 / 1204	0%	0	0 / 0
peripheral blood	96%	13306.87	893 / 929	0%	0	0 / 0
heart	94%	11728.24	806 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0060315	Biological process	negative regulation of ryanodine-sensitive calcium-release channel activity
GO_0051343	Biological process	positive regulation of cyclic-nucleotide phosphodiesterase activity
GO_0002027	Biological process	regulation of heart rate
GO_0032465	Biological process	regulation of cytokinesis
GO_0060316	Biological process	positive regulation of ryanodine-sensitive calcium-release channel activity
GO_0010881	Biological process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO_0010801	Biological process	negative regulation of peptidyl-threonine phosphorylation
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0098901	Biological process	regulation of cardiac muscle cell action potential
GO_0050848	Biological process	regulation of calcium-mediated signaling
GO_0021762	Biological process	substantia nigra development
GO_0031954	Biological process	positive regulation of protein autophosphorylation
GO_0000086	Biological process	G2/M transition of mitotic cell cycle
GO_1901842	Biological process	negative regulation of high voltage-gated calcium channel activity
GO_0010880	Biological process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO_0032516	Biological process	positive regulation of phosphoprotein phosphatase activity
GO_0010800	Biological process	positive regulation of peptidyl-threonine phosphorylation
GO_1905913	Biological process	negative regulation of calcium ion export across plasma membrane
GO_1901844	Biological process	regulation of cell communication by electrical coupling involved in cardiac conduction
GO_0055117	Biological process	regulation of cardiac muscle contraction
GO_0071902	Biological process	positive regulation of protein serine/threonine kinase activity
GO_0051592	Biological process	response to calcium ion
GO_0035307	Biological process	positive regulation of protein dephosphorylation
GO_0005513	Biological process	detection of calcium ion
GO_0005876	Cellular component	spindle microtubule
GO_1902494	Cellular component	catalytic complex
GO_0043209	Cellular component	myelin sheath
GO_0031982	Cellular component	vesicle
GO_0005886	Cellular component	plasma membrane
GO_0000922	Cellular component	spindle pole
GO_0005813	Cellular component	centrosome
GO_0032991	Cellular component	protein-containing complex
GO_0030017	Cellular component	sarcomere
GO_0034704	Cellular component	calcium channel complex
GO_0005737	Cellular component	cytoplasm
GO_0097225	Cellular component	sperm midpiece
GO_0008076	Cellular component	voltage-gated potassium channel complex
GO_0005634	Cellular component	nucleus
GO_0031432	Molecular function	titin binding
GO_0019901	Molecular function	protein kinase binding
GO_0043539	Molecular function	protein serine/threonine kinase activator activity
GO_0048306	Molecular function	calcium-dependent protein binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0008179	Molecular function	adenylate cyclase binding
GO_0072542	Molecular function	protein phosphatase activator activity
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding
GO_0010856	Molecular function	adenylate cyclase activator activity

IV. Literature review

[source]

Gene name	CALM3
Protein name	Calmodulin-3 Calmodulin 3
Synonyms	CAMC CAM3 CAMIII hCG_20313 CALML2
Description	FUNCTION: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding . Calcium-binding is required for the activation of calmodulin . Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases . Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis . .; FUNCTION: (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. .
Accessions	ENST00000596362.1 ENST00000291295.14 ENST00000597743.5 P0DP25 A0A590UJD7 M0QZ52 ENST00000602169.2

CALM3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review