FZD8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FZD8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FZD8 at tissue level.

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0033077Biological processT cell differentiation in thymus
GO_0030182Biological processneuron differentiation
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0035567Biological processnon-canonical Wnt signaling pathway
GO_0098992Cellular componentneuronal dense core vesicle
GO_1990851Cellular componentWnt-Frizzled-LRP5/6 complex
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005794Cellular componentGolgi apparatus
GO_0017147Molecular functionWnt-protein binding
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0005102Molecular functionsignaling receptor binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042813Molecular functionWnt receptor activity
GO_0030165Molecular functionPDZ domain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFZD8
Protein nameFrizzled-8 (Fz-8) (hFz8)
Synonyms
DescriptionFUNCTION: Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. .

AccessionsQ9H461
ENST00000374694.3