GPR52 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPR52 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR52 at tissue level.

III. Associated gene sets

GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0009584Biological processdetection of visible light
GO_0007602Biological processphototransduction
GO_0007626Biological processlocomotory behavior
GO_0071482Biological processcellular response to light stimulus
GO_0005886Cellular componentplasma membrane
GO_0008020Molecular functionG protein-coupled photoreceptor activity
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPR52
Protein nameG protein-coupled receptor 52
G-protein coupled receptor 52
SynonymshCG_1648322
DescriptionFUNCTION: Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization . May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum . Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation . .

AccessionsF2YGU0
ENST00000367685.5
Q9Y2T5