MRGPRX2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MRGPRX2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MRGPRX2 at tissue level.

III. Associated gene sets

GO_0019233Biological processsensory perception of pain
GO_0043303Biological processmast cell degranulation
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0032467Biological processpositive regulation of cytokinesis
GO_0030431Biological processsleep
GO_0045576Biological processmast cell activation
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0042923Molecular functionneuropeptide binding
GO_1990595Molecular functionmast cell secretagogue receptor activity
GO_0004930Molecular functionG protein-coupled receptor activity

IV. Literature review

[source]
Gene nameMRGPRX2
Protein nameMas-related G-protein coupled receptor member X2
SynonymsMRGX2
DescriptionFUNCTION: Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core . Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A. .

AccessionsQ96LB1
ENST00000329773.3