PIK3CB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002931Biological processresponse to ischemia
GO_0006897Biological processendocytosis
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0070527Biological processplatelet aggregation
GO_0007165Biological processsignal transduction
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0060055Biological processangiogenesis involved in wound healing
GO_0010628Biological processpositive regulation of gene expression
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0006935Biological processchemotaxis
GO_0006874Biological processintracellular calcium ion homeostasis
GO_1903671Biological processnegative regulation of sprouting angiogenesis
GO_0001952Biological processregulation of cell-matrix adhesion
GO_0035022Biological processpositive regulation of Rac protein signal transduction
GO_0048015Biological processphosphatidylinositol-mediated signaling
GO_2000369Biological processregulation of clathrin-dependent endocytosis
GO_0030168Biological processplatelet activation
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0036092Biological processphosphatidylinositol-3-phosphate biosynthetic process
GO_0003376Biological processsphingosine-1-phosphate receptor signaling pathway
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0033031Biological processpositive regulation of neutrophil apoptotic process
GO_0007156Biological processhomophilic cell adhesion via plasma membrane adhesion molecules
GO_0010508Biological processpositive regulation of autophagy
GO_0001935Biological processendothelial cell proliferation
GO_0045429Biological processpositive regulation of nitric oxide biosynthetic process
GO_0043409Biological processnegative regulation of MAPK cascade
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0040016Biological processembryonic cleavage
GO_1900747Biological processnegative regulation of vascular endothelial growth factor signaling pathway
GO_0006914Biological processautophagy
GO_0016310Biological processphosphorylation
GO_1903298Biological processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO_0016477Biological processcell migration
GO_0005730Cellular componentnucleolus
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0005942Cellular componentphosphatidylinositol 3-kinase complex
GO_0005654Cellular componentnucleoplasm
GO_0005943Cellular componentphosphatidylinositol 3-kinase complex, class IA
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0043560Molecular functioninsulin receptor substrate binding
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0016303Molecular function1-phosphatidylinositol-3-kinase activity
GO_0035005Molecular function1-phosphatidylinositol-4-phosphate 3-kinase activity
GO_0005515Molecular functionprotein binding
GO_0046934Molecular function1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity

IV. Literature review

[source]
Gene namePIK3CB
Protein namePhosphatidylinositol 3-kinase catalytic subunit type 3 (Phosphoinositide-3-kinase class 3)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1)
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CB protein
SynonymsPIK3C1
DKFZp779K1237
DescriptionFUNCTION: Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides . Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) . PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Has also a protein kinase activity showing autophosphorylation . .

AccessionsENST00000483968.5
F8WDJ8
H0Y871
ENST00000289153.6
ENST00000477593.5
H7C565
ENST00000473435.1
ENST00000465581.1
C9JYX0
ENST00000544716.5
H7C5C3
Q6PJ60
ENST00000462294.1
ENST00000674063.1
Q68DL0
P42338
C9J345
H7C527
ENST00000469284.6
ENST00000462898.5
ENST00000493568.5