I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell of lymphatic vessel | 30 studies | 81% ± 22% | |
| endothelial cell | 4 studies | 20% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell of lymphatic vessel | 30 studies | 81% ± 22% | |
| endothelial cell | 4 studies | 20% ± 3% |
Insufficient scRNA-seq data for expression of CCL21 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 96% | 6505.20 | 554 / 578 | 87% | 144.24 | 1008 / 1155 |
| intestine | 88% | 6433.38 | 851 / 966 | 61% | 89.86 | 324 / 527 |
| esophagus | 93% | 4143.67 | 1347 / 1445 | 56% | 95.82 | 103 / 183 |
| thymus | 99% | 18763.37 | 647 / 653 | 37% | 94.70 | 225 / 605 |
| stomach | 56% | 1664.14 | 200 / 359 | 64% | 82.52 | 182 / 286 |
| breast | 68% | 3473.68 | 314 / 459 | 47% | 46.87 | 529 / 1118 |
| prostate | 53% | 1191.38 | 131 / 245 | 60% | 34.46 | 301 / 502 |
| uterus | 66% | 1678.29 | 112 / 170 | 45% | 42.05 | 207 / 459 |
| bladder | 57% | 2344.67 | 12 / 21 | 52% | 52.33 | 262 / 504 |
| liver | 52% | 1006.95 | 118 / 226 | 50% | 175.73 | 204 / 406 |
| skin | 48% | 960.28 | 863 / 1809 | 48% | 354.78 | 225 / 472 |
| spleen | 94% | 5196.04 | 227 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 86% | 1195.25 | 25 / 29 |
| kidney | 57% | 2326.83 | 51 / 89 | 28% | 33.70 | 249 / 901 |
| pancreas | 8% | 83.59 | 26 / 328 | 76% | 175.91 | 136 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 78% | 177.77 | 35 / 45 |
| adrenal gland | 49% | 1140.44 | 127 / 258 | 24% | 19.14 | 55 / 230 |
| adipose | 69% | 3124.69 | 827 / 1204 | 0% | 0 | 0 / 0 |
| ovary | 41% | 981.58 | 74 / 180 | 25% | 19.26 | 106 / 430 |
| blood vessel | 29% | 1075.49 | 385 / 1335 | 0% | 0 | 0 / 0 |
| heart | 19% | 325.23 | 165 / 861 | 0% | 0 | 0 / 0 |
| muscle | 4% | 46.97 | 32 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.75 | 2 / 80 |
| brain | 0% | 0 | 0 / 2642 | 0% | 0.60 | 1 / 705 |
| peripheral blood | 0% | 5.06 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002407 | Biological process | dendritic cell chemotaxis |
| GO_0033630 | Biological process | positive regulation of cell adhesion mediated by integrin |
| GO_0030838 | Biological process | positive regulation of actin filament polymerization |
| GO_0001771 | Biological process | immunological synapse formation |
| GO_0006954 | Biological process | inflammatory response |
| GO_0031529 | Biological process | ruffle organization |
| GO_0043547 | Biological process | positive regulation of GTPase activity |
| GO_2000529 | Biological process | positive regulation of myeloid dendritic cell chemotaxis |
| GO_0097026 | Biological process | dendritic cell dendrite assembly |
| GO_0050921 | Biological process | positive regulation of chemotaxis |
| GO_0046330 | Biological process | positive regulation of JNK cascade |
| GO_0031295 | Biological process | T cell costimulation |
| GO_0038116 | Biological process | chemokine (C-C motif) ligand 21 signaling pathway |
| GO_0010820 | Biological process | positive regulation of T cell chemotaxis |
| GO_0001954 | Biological process | positive regulation of cell-matrix adhesion |
| GO_2000147 | Biological process | positive regulation of cell motility |
| GO_0002606 | Biological process | positive regulation of dendritic cell antigen processing and presentation |
| GO_0051209 | Biological process | release of sequestered calcium ion into cytosol |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0048260 | Biological process | positive regulation of receptor-mediated endocytosis |
| GO_0006955 | Biological process | immune response |
| GO_0001768 | Biological process | establishment of T cell polarity |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0051491 | Biological process | positive regulation of filopodium assembly |
| GO_0070098 | Biological process | chemokine-mediated signaling pathway |
| GO_0035759 | Biological process | mesangial cell-matrix adhesion |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
| GO_0034695 | Biological process | response to prostaglandin E |
| GO_0090023 | Biological process | positive regulation of neutrophil chemotaxis |
| GO_1990869 | Biological process | cellular response to chemokine |
| GO_1903237 | Biological process | negative regulation of leukocyte tethering or rolling |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0061844 | Biological process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| GO_0031274 | Biological process | positive regulation of pseudopodium assembly |
| GO_2000406 | Biological process | positive regulation of T cell migration |
| GO_0010560 | Biological process | positive regulation of glycoprotein biosynthetic process |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0048469 | Biological process | cell maturation |
| GO_2000669 | Biological process | negative regulation of dendritic cell apoptotic process |
| GO_2000548 | Biological process | negative regulation of dendritic cell dendrite assembly |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0008009 | Molecular function | chemokine activity |
| GO_0048020 | Molecular function | CCR chemokine receptor binding |
| GO_0042379 | Molecular function | chemokine receptor binding |
| GO_0031732 | Molecular function | CCR7 chemokine receptor binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CCL21 |
| Protein name | C-C motif chemokine 21 (6Ckine) (Beta-chemokine exodus-2) (Secondary lymphoid-tissue chemokine) (SLC) (Small-inducible cytokine A21) C-C motif chemokine ligand 21 |
| Synonyms | SCYA21 UNQ784/PRO1600 |
| Description | FUNCTION: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
| Accessions | ENST00000259607.7 O00585 ENST00000378792.1 Q5VZ73 |
