KISS1R report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KISS1R at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KISS1R at tissue level.

III. Associated gene sets

GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007218Biological processneuropeptide signaling pathway
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0009986Cellular componentcell surface
GO_0005929Cellular componentcilium
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0008528Molecular functionG protein-coupled peptide receptor activity
GO_0008188Molecular functionneuropeptide receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKISS1R
Protein nameKiSS-1 receptor (KiSS-1R) (G-protein coupled receptor 54) (G-protein coupled receptor OT7T175) (hOT7T175) (Hypogonadotropin-1) (Kisspeptins receptor) (Metastin receptor)
KISS1 receptor
SynonymsGPR54
AXOR12
DescriptionFUNCTION: Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. .

AccessionsENST00000592648.1
U3KQ86
Q969F8
ENST00000234371.10
ENST00000606939.2
K7EQ45