Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3119.65 | 1445 / 1445 | 100% | 80.52 | 183 / 183 |
| lung | 100% | 6476.47 | 578 / 578 | 100% | 58.40 | 1155 / 1155 |
| breast | 100% | 3861.97 | 459 / 459 | 100% | 64.89 | 1116 / 1118 |
| uterus | 100% | 3024.69 | 170 / 170 | 100% | 46.85 | 458 / 459 |
| brain | 100% | 2592.80 | 2632 / 2642 | 100% | 69.18 | 705 / 705 |
| ovary | 100% | 3415.29 | 180 / 180 | 99% | 32.60 | 427 / 430 |
| bladder | 100% | 3909.57 | 21 / 21 | 99% | 47.00 | 498 / 504 |
| thymus | 100% | 2841.18 | 652 / 653 | 99% | 36.50 | 597 / 605 |
| intestine | 100% | 4591.59 | 966 / 966 | 98% | 41.67 | 519 / 527 |
| stomach | 99% | 2661.96 | 356 / 359 | 99% | 49.37 | 282 / 286 |
| kidney | 100% | 2809.52 | 89 / 89 | 97% | 51.46 | 877 / 901 |
| prostate | 100% | 2737.15 | 244 / 245 | 98% | 29.77 | 490 / 502 |
| adrenal gland | 100% | 3894.36 | 258 / 258 | 96% | 32.38 | 221 / 230 |
| skin | 100% | 3195.53 | 1806 / 1809 | 96% | 57.05 | 453 / 472 |
| pancreas | 89% | 1134.15 | 291 / 328 | 99% | 44.74 | 176 / 178 |
| liver | 92% | 1759.79 | 207 / 226 | 91% | 24.12 | 371 / 406 |
| adipose | 100% | 4841.87 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3840.25 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 70.97 | 29 / 29 |
| muscle | 100% | 5122.15 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 4343.85 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 52.83 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 23.84 | 1 / 1 |
| peripheral blood | 99% | 7680.58 | 923 / 929 | 0% | 0 | 0 / 0 |
| heart | 93% | 1808.16 | 805 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 89% | 28.21 | 71 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007188 | Biological process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_1904706 | Biological process | negative regulation of vascular associated smooth muscle cell proliferation |
| GO_0007165 | Biological process | signal transduction |
| GO_0008217 | Biological process | regulation of blood pressure |
| GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
| GO_0030168 | Biological process | platelet activation |
| GO_0001569 | Biological process | branching involved in blood vessel morphogenesis |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0030154 | Biological process | cell differentiation |
| GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO_0007266 | Biological process | Rho protein signal transduction |
| GO_0010762 | Biological process | regulation of fibroblast migration |
| GO_0008360 | Biological process | regulation of cell shape |
| GO_1904753 | Biological process | negative regulation of vascular associated smooth muscle cell migration |
| GO_0031526 | Cellular component | brush border membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005834 | Cellular component | heterotrimeric G-protein complex |
| GO_0042470 | Cellular component | melanosome |
| GO_0005634 | Cellular component | nucleus |
| GO_0031683 | Molecular function | G-protein beta/gamma-subunit complex binding |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| GO_0031752 | Molecular function | D5 dopamine receptor binding |
| GO_0003925 | Molecular function | G protein activity |
| GO_0005525 | Molecular function | GTP binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003924 | Molecular function | GTPase activity |
| Gene name | GNA13 |
| Protein name | Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13) |
| Synonyms | |
| Description | FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems . Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) . GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway . Inhibits CDH1-mediated cell adhesion in process independent from Rho activation . . |
| Accessions | ENST00000541118.1 [Q14344-2] Q14344 ENST00000439174.7 [Q14344-1] |
