AKAP13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000165Biological processMAPK cascade
GO_0007507Biological processheart development
GO_0055007Biological processcardiac muscle cell differentiation
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0086023Biological processadenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0035023Biological processregulation of Rho protein signal transduction
GO_0060297Biological processregulation of sarcomere organization
GO_0060348Biological processbone development
GO_0035025Biological processpositive regulation of Rho protein signal transduction
GO_0071875Biological processadrenergic receptor signaling pathway
GO_0016020Cellular componentmembrane
GO_0030864Cellular componentcortical actin cytoskeleton
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0005634Cellular componentnucleus
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0005078Molecular functionMAP-kinase scaffold activity
GO_0031267Molecular functionsmall GTPase binding
GO_0046872Molecular functionmetal ion binding
GO_0051018Molecular functionprotein kinase A binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAKAP13
Protein nameA-kinase anchoring protein 13
AKAP13 protein
A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)
AKAP13
SynonymsHT31
LBC
BRX
DescriptionFUNCTION: Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor . May also activate other Rho family members . Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 . Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity . Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 . Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 . Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 . Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac . Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol . Required for normal adaptive cardiac hypertrophy in response to pressure overload . Plays a role in osteogenesis (By similarity). .

AccessionsENST00000612418.1
A0A087WTD7
H0YMW2
ENST00000560579.5
H0YK18
ENST00000560256.1
ENST00000558811.2
A0A087WYS7
ENST00000559486.2
ENST00000560302.5 [Q12802-5]
ENST00000394510.6
B7ZW05
A0A087X047
H0YK84
ENST00000559362.5
ENST00000394518.7 [Q12802-1]
ENST00000560340.5
A0A087WY36
ENST00000557852.2
H0YLH1
ENST00000558166.2
ENST00000361243.6 [Q12802-2]
A8MYJ1
A0A087WX73
H0YMI5
Q12802
A0A2X0SF55
ENST00000560676.5